高血压大鼠线粒体功能和钙摄取随年龄变化的情况。
Changes in mitochondrial functionality and calcium uptake in hypertensive rats as a function of age.
作者信息
Calderón-Cortés E, Cortés-Rojo C, Clemente-Guerrero M, Manzo-Avalos S, Villalobos-Molina R, Boldogh I, Saavedra-Molina A
机构信息
Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-3. C.U., Morelia, Mich. 58030, Mexico.
出版信息
Mitochondrion. 2008 Jun;8(3):262-72. doi: 10.1016/j.mito.2008.04.005. Epub 2008 May 4.
Abstract
We studied whether mitochondrial functions and Ca2+ metabolism were altered in Wistar Kyoto normotensive (WKY) and spontaneous hypertensive rats (SHR). Ca2+ uptake was decreased in SHR compared to WKY rats. Accumulation of Ca2+ was more efficient in WKY than in SHR rats. mDeltaPsi was lower in SHR compared to WKY rats. Basal complex IV activity was higher in SHR than WKY rats, whereas basal L-citrulline production, an indicator of nitric oxide synthesis, was decreased in SHR and dependent on Ca2+ concentration (p<0.05). Impact of Ca2+ was counteracted by EGTA. These data show an age-dependent decreased mitochondrial functions in brain mitochondria during hypertension.
摘要
我们研究了Wistar Kyoto正常血压大鼠（WKY）和自发性高血压大鼠（SHR）的线粒体功能及Ca2+代谢是否发生改变。与WKY大鼠相比，SHR的Ca2+摄取减少。WKY大鼠中Ca2+的积累比SHR大鼠更有效。与WKY大鼠相比，SHR的线粒体膜电位（mDeltaPsi）更低。SHR的基础复合物IV活性高于WKY大鼠，而作为一氧化氮合成指标的基础L-瓜氨酸生成在SHR中降低且依赖于Ca2+浓度（p<0.05）。EGTA可抵消Ca2+的影响。这些数据表明高血压期间脑线粒体的线粒体功能存在年龄依赖性下降。
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