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[自发性蛛网膜下腔出血:462例患者的研究]

[Spontaneous subarachnoid haemorrhage: a study of 462 patients].

作者信息

Parkhutik V, Lago A, Tembl J I, Beltrán A, Fuset M P

机构信息

Servicio de Neurología, Hospital Universitario La Fe, Valencia, España.

出版信息

Rev Neurol. 2008;46(12):705-8.

Abstract

AIMS

To describe the demographic characteristics of patients with spontaneous subarachnoid haemorrhage (SAH) in our population and to compare the endovascular and surgical treatment of intracranial aneurysms.

PATIENTS AND METHODS

We conducted a retrospective study of 462 patients who were admitted to the Hospital Universitario La Fe in Valencia between April 1997 and March 2005.

RESULTS

The mean age was 56.8 +/- 14.8 years and 55.8% of the patients were females. The risk factors were: arterial hypertension, 40.3%; smoking, 32.7%; dyslipidemia, 16.0%; diabetes mellitus, 10.6%; alcoholism, 6.7%. A cerebral arteriography was performed in 369 patients and intracranial aneurysms were detected in 246 of them. Aneurysms were treated by embolisation in 62.6% of cases and by surgery in 22%. On comparing the embolisation and surgery groups, there were non-significant differences in the rates of complications. Infections were present in 21.9% of patients in the embolisation group versus 10.2% in the surgery group; epileptic seizures 6.1% versus 8%; hydrocephalus 2.7% versus 4%; rebleeding 4.1% versus 10.2%; clinical vasospasm 8.9% versus 6.1%. The rate of sequelae on discharge (a score on the modified Rankin Scale > 3) was 13.7% among surviving patients in the embolisation group and 15.5% in the group that had undergone surgery. The mortality rates in the two groups were 10.3 and 10%, respectively. Overall mortality rate was 30.1%.

CONCLUSIONS

The presentation and course of SAH in our population follow a pattern that is similar to those reported in other countries. No differences in morbidity and mortality were detected between the endovascular and surgical treatment of ruptured intracranial aneurysms.

摘要

目的

描述我们所研究人群中自发性蛛网膜下腔出血(SAH)患者的人口统计学特征,并比较颅内动脉瘤的血管内治疗和外科治疗。

患者与方法

我们对1997年4月至2005年3月间入住巴伦西亚拉费大学医院的462例患者进行了一项回顾性研究。

结果

平均年龄为56.8±14.8岁,55.8%的患者为女性。危险因素包括:动脉高血压,40.3%;吸烟,32.7%;血脂异常,16.0%;糖尿病,10.6%;酗酒,6.7%。369例患者进行了脑血管造影,其中246例检测到颅内动脉瘤。62.6%的病例采用栓塞治疗动脉瘤,22%采用手术治疗。比较栓塞组和手术组,并发症发生率无显著差异。栓塞组21.9%的患者发生感染,手术组为10.2%;癫痫发作率分别为6.1%和8%;脑积水发生率分别为2.7%和4%;再出血率分别为4.1%和10.2%;临床血管痉挛发生率分别为8.9%和6.1%。栓塞组存活患者出院时的后遗症发生率(改良Rankin量表评分>3)为13.7%,手术组为15.5%。两组的死亡率分别为10.3%和10%。总体死亡率为30.1%。

结论

我们所研究人群中SAH的表现和病程与其他国家报道的相似。颅内破裂动脉瘤的血管内治疗和外科治疗在发病率和死亡率方面未发现差异。

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