[过敏性紫癜性肾炎患儿血浆血栓素A2和前列腺素I2水平及其比值]

[Plasma thromboxane A2 and prostaglandin I2 levels and their ratio in children with Henoch-Schonlein purpura nephritis].

作者信息

Lu Xue-Yun, Yang Huan-Yun, Yang Qiao-Zhi, Liang Jun, Zhu Yan-Ping, Dong Sheng-Ying, Sun Wen-Ying

机构信息

Department of Pediatrics, Liaocheng People's Hospital, Liaocheng, Shandong 252000, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2008 Jun;10(3):343-5.

PMID:18554464

Abstract

OBJECTIVE

To study the changes and roles of plasma thromboxane A2 (TXA2) and prostaglandin I2 (PGT2) levels and their ratio in Henoch-Schonlein purpura nephritis (HSPN) in children.

METHODS

Plasma levels of TXA2 and PGI2 were measured using ELISA in 45 children with HSPN and 20 healthy children.

RESULTS

Plasma TXA2 level was significantly higher, while plasma PGI2 level was significantly lower in HSPN children in the acute phase than in the control (P<0.01). The ratio of TXA2/PGI2 in HSPN children in the acute phase was statistically higher than in the control (9.55+/-3.56 vs 0.87+/-0.21; P<0.01). In the convalescence phase, plasma TXA2 level remained higher and plasma PGI2 level was elevated and higher than in the control, so the ratio of TXA2/PGI2 was reduced to normal level.

CONCLUSIONS

The imbalance of TXA2 and PGI2 may be involved in the development of renal damage in children with HSPN. The balance of TXA2 and PGI2 contributes to renal recovery.

摘要

目的

研究儿童过敏性紫癜性肾炎（HSPN）血浆血栓素A2（TXA2）、前列环素I2（PGI2）水平及其比值的变化和作用。

方法

采用酶联免疫吸附测定法（ELISA）检测45例HSPN患儿和20例健康儿童血浆TXA2、PGI2水平。

结果

急性期HSPN患儿血浆TXA2水平显著高于对照组，血浆PGI2水平显著低于对照组（P<0.01）。急性期HSPN患儿TXA2/PGI2比值高于对照组（9.55±3.56比0.87±0.21；P<0.01）。恢复期，血浆TXA2水平仍高于对照组，血浆PGI2水平升高且高于对照组，TXA2/PGI2比值降至正常水平。