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[原发性肾上腺非霍奇金淋巴瘤所致肾上腺功能衰竭:一例报告并文献复习]

[Adrenal failure caused by primary adrenal non-Hodgkin lymphoma: a case report and review of the literature].

作者信息

Hernández Marín B, Díaz Muñoz de la Espada V M, Alvarez Alvarez R, Encinas García S, Khosravi Shahi P, Pérez Fernández R, Pérez Manga G

机构信息

Servicio de Oncología Médica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

出版信息

An Med Interna. 2008 Mar;25(3):131-3. doi: 10.4321/s0212-71992008000300007.

Abstract

We report a case of 78-year old man who presented with symptoms of adrenal insufficiency. The computed tomography (CT) scan showed the presence of bilateral adrenal masses. A CT-scan guided needle biopsy revealed diffuse large- B cell lymphoma. The absence of pathological findings in clinical, bone marrow and CT scan examinations supported the diagnosis of primary non-Hodgkin Lymphoma of the adrenal glands. The patient was treated with four cycles of R-CHOP chemotherapy with Rituximab, liposomal Doxorubicin, Cyclophosphamide, Vincristine and Prednisolone. At the end of fourth cycle there was radiological improvement but the chemotherapy was stopped because of IV grade toxicity. He completed treatment with radiotherapy of right adrenal mass. Few days after finishing radiation therapy the patient died due to a disseminated infection. No progressive disease was founded.

摘要

我们报告一例78岁男性患者,其表现出肾上腺功能不全的症状。计算机断层扫描(CT)显示双侧肾上腺有肿块。CT引导下针吸活检显示为弥漫性大B细胞淋巴瘤。临床、骨髓和CT扫描检查均未发现病理结果,支持肾上腺原发性非霍奇金淋巴瘤的诊断。该患者接受了四个周期的R-CHOP化疗,药物包括利妥昔单抗、脂质体阿霉素、环磷酰胺、长春新碱和泼尼松龙。在第四个周期结束时,影像学有改善,但由于IV级毒性反应,化疗停止。他接受了右肾上腺肿块的放射治疗。放疗结束几天后,患者因播散性感染死亡。未发现疾病进展。

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