头颈部黏液表皮样癌：43例患者的临床分析
Mucoepidermoid carcinoma of the head and neck: clinical analysis of 43 patients.
作者信息
Ozawa Hiroyuki, Tomita Toshiki, Sakamoto Koji, Tagawa Takamasa, Fujii Ryoichi, Kanzaki Sho, Ogawa Kaoru, Kameyama Kaori, Fujii Masato
机构信息
Department of Otolaryngology, School of Medicine Keio University, Tokyo, Japan.
出版信息
Jpn J Clin Oncol. 2008 Jun;38(6):414-8. doi: 10.1093/jjco/hyn045.
OBJECTIVE
It is well known that mucoepidermoid carcinoma (MEC) displays a variety of biological behaviors. While the high-grade type is a highly aggressive tumor, its low-grade counterpart usually demonstrates a more benign nature and several systems have, therefore, been proposed to grade this neoplasm.
METHODS
This report analyzes 43 patients suffering from head and neck MEC, who were treated in our department during the period from 1989 to 2005. The relationship between clinical and pathologic characteristics and survival rate was investigated.
RESULTS
The 5-year overall and disease-free survival rate was 62.3 and 57.2%. Multivariate analysis demonstrated that the parameters that significantly affected survival were the patient's age (P = 0.040) and treatment method (P = 0.011).
CONCLUSIONS
The patient's age and treatment method is the prognostic parameter in this study. Although complete surgical resection is the standard treatment for MEC, we should aggressively consider adjunctive radiotherapy in those cases that have a high risk of recurrence and poor prognosis.
目的
众所周知，黏液表皮样癌（MEC）表现出多种生物学行为。高级别类型是一种高度侵袭性肿瘤，而低级别类型通常表现出更良性的性质，因此已提出多种系统对该肿瘤进行分级。
方法
本报告分析了1989年至2005年期间在我科接受治疗的43例头颈部黏液表皮样癌患者。研究了临床和病理特征与生存率之间的关系。
结果
5年总生存率和无病生存率分别为62.3%和57.2%。多因素分析表明，显著影响生存的参数是患者年龄（P = 0.040）和治疗方法（P = 0.011）。
结论
患者年龄和治疗方法是本研究中的预后参数。虽然完整的手术切除是黏液表皮样癌的标准治疗方法，但对于那些复发风险高且预后差的病例，我们应积极考虑辅助放疗。
Zotero 插件