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Inhibitors of sterol biosynthesis as Staphylococcus aureus antibiotics.

作者信息

Walsh Christopher T, Fischbach Michael A

机构信息

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Angew Chem Int Ed Engl. 2008;47(31):5700-2. doi: 10.1002/anie.200801801.

Abstract
摘要

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本文引用的文献

1
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science. 2008 Mar 7;319(5868):1391-4. doi: 10.1126/science.1153018. Epub 2008 Feb 14.
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Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization.
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Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.
J Biol Chem. 2000 Sep 29;275(39):30610-7. doi: 10.1074/jbc.M004132200.
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Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway.
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