仿生亚硒酸盐和硒酸盐。

Biomimetic seleninates and selenonates.

作者信息

Abdo Mohannad, Knapp Spencer

机构信息

Department of Chemistry & Chemical Biology, Rutgers-The State University of New Jersey, Piscataway, New Jersey 08854, USA.

出版信息

J Am Chem Soc. 2008 Jul 23;130(29):9234-5. doi: 10.1021/ja8034448. Epub 2008 Jun 25.

DOI:10.1021/ja8034448

PMID:18576651

Abstract

The synthesis of a variety of pyranose-, nucleoside-, (amino acid)-, and polyhydric-based seleninic and selenonic acids by DMDO oxidation of the corresponding selenoesters is reported, as well as some unusual coupling reactions of the seleninate and selenonate functionality with biological nucleophilic groups (sulfhydryl, indole, phenol, imidazole, carboxamide) that are found in proteins and enzyme active sites.

摘要

报道了通过相应的亚硒酸酯的二甲基二氧杂环丙烷（DMDO）氧化合成多种基于吡喃糖、核苷、（氨基酸）和多元醇的亚硒酸和硒酸，以及亚硒酸酯和硒酸酯官能团与蛋白质和酶活性位点中存在的生物亲核基团（巯基、吲哚、苯酚、咪唑、羧酰胺）的一些不寻常的偶联反应。