Arama Victoria, Vladareanu Radu, Mihailescu Raluca, Streinu Cercel Adrian, Mihai Carina, Hristea Adriana, Iosipenco Mihaela, Arama Sorin Stefan, Rabilloud Muriel
Department Adults 3 of National Institute of Infectious Diseases Professor Dr. Matei Bals, Bucharest, Romania.
J Perinat Med. 2008;36(3):206-12. doi: 10.1515/JPM.2008.046.
To estimate the type-specific seroprevalence and identify the risk factors associated with herpes simplex virus (HSV)-2 infection in pregnant women in Bucharest, Romania.
A prospective survey was conducted in 452 subjects, aged 15-39 years, at the Elias Hospital, during the years 2004-2005. We evaluated serum IgG anti-bodies to HSV-1 and HSV-2 using the HerpeSelect ELISA test. All subjects completed an epidemiological questionnaire.
Seroprevalence was 87.3% and 15.1% for HSV-1 and HSV-2, respectively. The risk factors for HSV-2 infection were lower level of education and a greater number of sexual partners. Elementary school and high-school graduates were 6.28 and 2.26 times more exposed than University graduates. Having 2-3 partners and more than three partners was associated with 2.43 and 4.26 times the risk of acquiring HSV-2, compared with having one partner.
In pregnant women, HSV-1 seroprevalence was higher than in Western Europe but similar to that in Eastern Europe. HSV-2 seroprevalence was within European ranges. Both were lower than in the USA. Risk factors for HSV-2 infection may lead to prevention programs.
估计罗马尼亚布加勒斯特孕妇单纯疱疹病毒（HSV）-2感染的型特异性血清流行率，并确定与之相关的危险因素。
2004年至2005年期间，在埃利亚斯医院对452名年龄在15至39岁之间的受试者进行了一项前瞻性调查。我们使用HerpeSelect ELISA检测法评估了血清中针对HSV-1和HSV-2的IgG抗体。所有受试者均完成了一份流行病学调查问卷。
HSV-1和HSV-2的血清流行率分别为87.3%和15.1%。HSV-2感染的危险因素是教育程度较低和性伴侣数量较多。小学和高中毕业生感染HSV-2的风险分别是大学毕业生的6.28倍和2.26倍。与只有一个性伴侣相比，有2至3个性伴侣和超过3个性伴侣感染HSV-2的风险分别是其2.43倍和4.26倍。
孕妇中，HSV-1的血清流行率高于西欧，但与东欧相似。HSV-2的血清流行率在欧洲范围内。两者均低于美国。HSV-2感染的危险因素可能有助于制定预防计划。
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