小儿人类免疫缺陷病毒感染与循环IgD⁺记忆B细胞
Pediatric human immunodeficiency virus infection and circulating IgD+ memory B cells.
作者信息
Jacobsen Marianne C, Thiébaut Rodolphe, Fisher Christopher, Sefe Delali, Clapson Margaret, Klein Nigel, Baxendale Helen E
机构信息
Infectious Diseases and Microbiology Unit, Hugh and Catherine Stevenson Centre for Childhood Infectious Diseases and Immunology, Institute of Child Health, University College London, United Kingdom.
出版信息
J Infect Dis. 2008 Aug 15;198(4):481-5. doi: 10.1086/590215.
Levels of circulating naive and memory B cells were measured in human immunodeficiency virus (HIV)-infected children and control subjects to determine whether the irreversible depletion of memory B cells described in HIV-infected adults occurs in children with HIV infection. Depletion of circulating IgD+ memory B cells was seen in HIV-infected children despite control of the HIV load with highly active antiretroviral therapy (HAART) (P =. 04). IgD+ memory B cell percentages did not correlate with CD4+ cell percentages (P =. 027) or disease duration (P =. 026). Naive/transitional and IgD- memory B cell numbers were not affected. Pediatric HIV infection is associated with selective depletion of circulating IgD+ memory B cells despite control of the HIV load with HAART.
在人类免疫缺陷病毒（HIV）感染儿童和对照受试者中测量循环中初始B细胞和记忆B细胞的水平，以确定HIV感染成人中所描述的记忆B细胞不可逆耗竭是否发生在HIV感染儿童中。尽管通过高效抗逆转录病毒疗法（HAART）控制了HIV载量，但在HIV感染儿童中仍可见循环IgD⁺记忆B细胞的耗竭（P = 0.04）。IgD⁺记忆B细胞百分比与CD4⁺细胞百分比（P = 0.027）或疾病持续时间（P = 0.026）均无相关性。初始/过渡性B细胞和IgD⁻记忆B细胞数量未受影响。尽管通过HAART控制了HIV载量，但儿童HIV感染仍与循环IgD⁺记忆B细胞的选择性耗竭有关。
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