癌症生物学中的亲吻素（KiSS-1）/G蛋白偶联受体54（GPR54）系统
The kisspeptin (KiSS-1)/GPR54 system in cancer biology.
作者信息
Makri Angeliki, Pissimissis Nikolaos, Lembessis Peter, Polychronakos Constantine, Koutsilieris Michael
机构信息
Department of Experimental Physiology, Medical School, National and Kapodistrian, University of Athens, 75 Micras Asias, Goudi-Athens 115 27, Greece.
出版信息
Cancer Treat Rev. 2008 Dec;34(8):682-92. doi: 10.1016/j.ctrv.2008.05.007. Epub 2008 Jun 25.
Kisspeptin (KiSS-1) gene, initially described as a melanoma metastasis suppressor gene, encodes a number of peptides (kp-54, kp-14, kp-13, kp-10), which are endogenous ligands to a G protein-coupled receptor, referred as hOT7T175 or AXOR12 or GPR54. So far intensive investigation has provided substantiate evidence supporting the role of KiSS-1/GPR54 system in cancer biology as well as in the regulation of the reproductive function and trophoblast invasion. The precise mechanism by which KiSS-1/GPR54 system is affecting cancer cell growth and metastasis includes complex endocrine, paracrine and autocrine actions. Nevertheless, the detail mechanism of such actions is still under intensive investigation. Herein we review the evidence which support the role of KiSS-1/GPR54 system in cancer biology.
亲吻素（KiSS-1）基因最初被描述为一种黑色素瘤转移抑制基因，它编码多种肽（kp-54、kp-14、kp-13、kp-10），这些肽是一种G蛋白偶联受体的内源性配体，该受体被称为hOT7T175或AXOR12或GPR54。到目前为止，深入研究已提供确凿证据，支持KiSS-1/GPR54系统在癌症生物学以及生殖功能和滋养层细胞侵袭调节中的作用。KiSS-1/GPR54系统影响癌细胞生长和转移的确切机制包括复杂的内分泌、旁分泌和自分泌作用。然而，此类作用的详细机制仍在深入研究中。在此，我们综述支持KiSS-1/GPR54系统在癌症生物学中作用的证据。
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