紫杉醇BC环系统合成中的关环复分解反应。

Ring-closing metathesis in the synthesis of BC ring-systems of taxol.

作者信息

Ma Cong, Schiltz Stéphanie, Le Goff Xavier F, Prunet Joëlle

机构信息

Laboratoire de Synthèse Organique, CNRS UMR 7652, Ecole Polytechnique, DCSO, Palaiseau Cedex, France.

出版信息

Chemistry. 2008;14(24):7314-23. doi: 10.1002/chem.200800774.

DOI:10.1002/chem.200800774

PMID:18600828

Abstract

BC ring-systems of taxol with different or no protecting group for the C1,C2-diol moiety have been efficiently synthesized. The eight-membered B ring is formed by a ring-closing metathesis reaction (RCM) between the C10 and C11 carbon atoms. The influence of the 1,2-diol protecting group on the RCM reaction has been studied in detail.

摘要

已经高效合成了紫杉醇的BC环系统，其C1、C2 -二醇部分具有不同的保护基团或无保护基团。八元B环由C10和C11碳原子之间的闭环复分解反应（RCM）形成。详细研究了1,2 -二醇保护基团对RCM反应的影响。