在一个65至69岁的社区样本中，APOE基因分型与认知衰退的关联以及与风险因素的相互作用。
The association of APOE genotype and cognitive decline in interaction with risk factors in a 65-69 year old community sample.
作者信息
Christensen Helen, Batterham Philip J, Mackinnon Andrew J, Jorm Anthony F, Mack Holly A, Mather Karen A, Anstey Kaarin J, Sachdev Perminder S, Easteal Simon
机构信息
The Australian National University, Canberra, Australia.
出版信息
BMC Geriatr. 2008 Jul 14;8:14. doi: 10.1186/1471-2318-8-14.
BACKGROUND
While the evidence of an association between the apolipoprotein E (APOE) *E4 allele and Alzheimer's disease is very strong, the effect of the *E4 allele on cognitive decline in the general population is more equivocal. A cross-sectional study on the lifespan effects of the *E4 allele 1 failed to find any effect of the *E4 allele on cognitive performance at ages 20-24, 40-44 or 60-64 years.
METHODS
In this four year follow-up study, we reexamine the effect of *E4 in the sample of 2,021 individuals, now aged 65-69 years.
RESULTS
Performance on the Mini-Mental State Examination (MMSE) was significantly poorer for *E4 homozygotes than heterozygotes or non-carriers. The effects of the *E4 genotype on cognitive decline over four years were found on the MMSE and Symbol-Digit Modalities test but only when controlling for risk factors such as head injury and education. Analyses were repeated with the exclusion of participants diagnosed with a mild cognitive disorder, with little change.
CONCLUSION
It is possible that *E4 carriers become vulnerable to greater cognitive decline in the presence of other risk factors at 65-69 years of age.
背景
虽然载脂蛋白E（APOE）E4等位基因与阿尔茨海默病之间存在关联的证据非常确凿，但E4等位基因对普通人群认知能力下降的影响却更不明确。一项关于*E4等位基因寿命影响的横断面研究未能发现该等位基因在20 - 24岁、40 - 44岁或60 - 64岁时对认知表现有任何影响。
方法
在这项为期四年的随访研究中，我们重新审视了*E4在2021名年龄在65 - 69岁个体样本中的影响。
结果
*E4纯合子在简易精神状态检查表（MMSE）上的表现明显比杂合子或非携带者差。*E4基因型对四年间认知能力下降的影响在MMSE和符号数字模式测试中被发现，但仅在控制诸如头部受伤和教育程度等风险因素时才成立。在排除被诊断患有轻度认知障碍的参与者后重复进行分析，结果变化不大。
结论
*E4携带者在65 - 69岁时，在存在其他风险因素的情况下，有可能更容易出现更大程度的认知能力下降。
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