一种来自爬山虎的新型芪糖苷对小鼠的抗疟活性。
Antimalarial activity of a new stilbene glycoside from Parthenocissus tricuspidata in mice.
作者信息
Park Won-Hwan, Lee Sung-Jae, Moon Hyung-In
机构信息
Department of Diagnostics and Cardiovascular Medical Research Center, College of Korean Medicine, Dongguk University, Gyeong-Ju, South Korea.
出版信息
Antimicrob Agents Chemother. 2008 Sep;52(9):3451-3. doi: 10.1128/AAC.00562-08. Epub 2008 Jul 14.
Abstract
A novel stilbene glycoside [piceid-(1-->6)-beta-d-glucopyranoside; PBG] from Parthenocissus tricuspidata was tested in vivo against Plasmodium berghei. PBG exhibited significant blood schizontocidal activity in a 4-day early infection, a repository evaluation, and an established infection, with a significant mean survival time comparable to that obtained with the standard drug, chloroquine (5 mg x kg(-1) x day(-1)).
摘要
从爬山虎中提取的一种新型芪糖苷[白藜芦醇-(1→6)-β-D-吡喃葡萄糖苷；PBG]在体内针对伯氏疟原虫进行了测试。PBG在4天的早期感染、储存评估和已建立的感染中均表现出显著的血裂殖体杀灭活性，其平均生存时间显著，与标准药物氯喹（5毫克×千克⁻¹×天⁻¹）相当。
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