Finger R P, Scholl H P N, Holz F G
Universitäts-Augenklinik Bonn, Ernst-Abbe-Strasse 2, 53127, Bonn, Deutschland.
Ophthalmologe. 2008 Aug;105(8):722-6. doi: 10.1007/s00347-008-1804-1.
The use of patient-reported outcomes (PROs) - standardized assessments by the patient of the impact of illness or therapy - has been met with increasing interest over the last years. Evidence generated from PROs is used not only to support claims in the drug regulatory process but is also used in political decision making and activities by the pharmaceutical industry. PROs can reflect the benefits of a treatment very well because the patient's quality of life is a central variable, and its preservation or improvement is certainly the main objective of any therapeutic intervention. The routine use of PROs is still hampered by several methodological problems. However, there are a number of advantages, such as improved interaction between physicians and patients and shared decision making, that may result in increased compliance.
患者报告结局(PROs)的使用——即由患者对疾病或治疗影响进行的标准化评估——在过去几年中受到了越来越多的关注。PROs产生的证据不仅用于支持药品监管过程中的主张,还用于制药行业的政治决策和活动。PROs能够很好地反映治疗的益处,因为患者的生活质量是一个核心变量,而其维持或改善无疑是任何治疗干预的主要目标。PROs的常规使用仍然受到一些方法学问题的阻碍。然而,PROs也有许多优点,比如改善医患之间的互动以及共同决策,这可能会提高依从性。