Pemberton L A, Stone E, Price P, van Bockxmeer F, Brew B J
Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia.
HIV Med. 2008 Oct;9(8):677-80. doi: 10.1111/j.1468-1293.2008.00614.x. Epub 2008 Jul 8.
Host genetic factors implicated in AIDS dementia complex (ADC) were studied.
DNA from ADC patients (n=56), unselected HIV-seropositive patients (n=112, 171, 185 and 204) and HIV-seronegative controls (n=204, 60, 60, 96 and 624) were typed for polymorphic loci in genes encoding tumour necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-12 and Apolipoprotein E (ApoE). Diagnosis of ADC was based on neurological symptoms, signs and neuroimaging findings with other causes of dementia excluded. Patients selected had ADC stage > or =1 and CD4 counts of <500 cells/microL.
Allele 2 of TNFA-308 was more common in ADC patients compared to HIV-positive or HIV-negative controls (P=0.005, 0.024). No other differences between ADC patients and control groups were significant. Meta-analyses confirmed these results.
This study suggests that TNFA-308 allele 2 or an allele in linkage disequilibrium with this locus influences ADC.
研究与艾滋病痴呆综合征（ADC）相关的宿主遗传因素。
对ADC患者（n = 56）、未经选择的HIV血清阳性患者（n = 112、171、185和204）以及HIV血清阴性对照者（n = 204、60、60、96和624）的DNA进行肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1α、IL-1β、IL-12和载脂蛋白E（ApoE）编码基因多态性位点的分型。ADC的诊断基于神经症状、体征和神经影像学检查结果，排除其他痴呆病因。入选患者的ADC分期≥1且CD4细胞计数<500个/微升。
与HIV阳性或HIV阴性对照者相比，TNFA - 308的2等位基因在ADC患者中更为常见（P = 0.005，0.024）。ADC患者与对照组之间的其他差异均无统计学意义。荟萃分析证实了这些结果。
本研究提示TNFA - 308的2等位基因或与该位点处于连锁不平衡的一个等位基因影响ADC。
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