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根尖手术治疗的70例根尖周病变在12个月时的组织学诊断与病情发展的关系

Relationship between histological diagnosis and evolution of 70 periapical lesions at 12 months, treated by periapical surgery.

作者信息

Carrillo Celia, Peñarrocha Miguel, Bagán José Vicente, Vera Francisco

机构信息

Valencia University Medical and Dental School, Valencia, Spain.

出版信息

J Oral Maxillofac Surg. 2008 Aug;66(8):1606-9. doi: 10.1016/j.joms.2007.12.014.

Abstract

PURPOSE

To relate the histologic diagnosis and radiographic size with the prognosis of 70 biopsies obtained via periapical surgery.

MATERIALS AND METHODS

Seventy biopsies obtained during periapical surgery were histologically analyzed following curettage of the tissue, establishing the diagnosis as either apical granuloma, radicular cyst, or scar tissue. The radiographic size of the lesion (area in mm(2)) before surgery and after 1 year of follow-up was measured. The evolution at 12 months after surgery was evaluated according to the criteria of von Arx and Kurt. A statistical study was made, the inter-variable relationships were studied using analysis of variance with subsequent Tukey testing and calculation of Pearson correlation coefficient.

RESULTS

Results indicated that 65.7% of lesions were granulomas, 25.7% scar tissue, and 8.6% cysts. The larger lesions had the worst prognosis. Cysts had the worst evolution at 12 months after surgery, this result being statistically significant.

CONCLUSIONS

The prognosis for the periapical lesion depended on the type of lesion and its radiographic size, with cysts and larger lesions having the worst evolution.

摘要

目的

探讨经根尖手术获取的70份活检组织的组织学诊断、影像学大小与预后的关系。

材料与方法

对根尖手术中获取的70份活检组织进行刮除术后组织学分析,诊断为根尖肉芽肿、根囊肿或瘢痕组织。测量术前及随访1年后病变的影像学大小(面积,单位为mm²)。根据冯·阿克斯和库尔特的标准评估术后12个月的病情进展。进行统计学研究,采用方差分析及后续的图基检验研究变量间关系,并计算皮尔逊相关系数。

结果

结果表明,65.7%的病变为肉芽肿,25.7%为瘢痕组织,8.6%为囊肿。病变越大,预后越差。囊肿在术后12个月的病情进展最差,这一结果具有统计学意义。

结论

根尖病变的预后取决于病变类型及其影像学大小,囊肿和较大病变的病情进展最差。

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