Chen Yu, Zhang Weiping, Geng Ning, Tian Kun, Jack Windsor Lester
Department of Oral Pathology, West China College of Stomatology, Sichuan University, Chengdu, China.
Head Neck. 2008 Sep;30(9):1237-45. doi: 10.1002/hed.20869.
Matrix metalloproteinases (MMPs) and transforming growth factor-beta1 (TGF-beta1) are important in many physiological and pathological processes.
Immunohistochemistry for MMP-2, MMP-9, membrane-type 1 MMP (MT1-MMP, MMP-14), tissue inhibitor of matrix metalloproteinase (TIMP)-2, and TGF-beta were performed on normal mucosa, nonatrophic oral lichen planus, atrophic oral lichen planus, and oral squamous cell carcinomas (OSCC) resulting from lichen planus.
Expression of MMPs progressively increased from normal mucosa to nonatrophic oral lichen planus, atrophic oral lichen planus, and OSCCs. Immunoscores of MMPs in atrophic oral lichen planus was significantly greater than nonatrophic oral lichen planus. Moreover, immunoscore of MMP-9 of OSCCs was significantly greater than both atrophic and nonatrophic lichen planus. Furthermore, expression of TIMP-2 and TGF-beta1 paralleled increases seen with MMPs.
Imbalance between MMPs and TIMPs may be involved in cancerization of oral lichen planus. MMP-2, MT1-MMP, and especially MMP-9 may be useful markers for judging potency of malignant transformation from oral lichen planus.
基质金属蛋白酶（MMPs）和转化生长因子-β1（TGF-β1）在许多生理和病理过程中都很重要。
对正常黏膜、非萎缩性口腔扁平苔藓、萎缩性口腔扁平苔藓以及由扁平苔藓引起的口腔鳞状细胞癌（OSCC）进行MMP-2、MMP-9、膜型1基质金属蛋白酶（MT1-MMP，MMP-14）、基质金属蛋白酶组织抑制剂（TIMP）-2和TGF-β的免疫组化检测。
MMPs的表达从正常黏膜到非萎缩性口腔扁平苔藓、萎缩性口腔扁平苔藓和OSCC逐渐增加。萎缩性口腔扁平苔藓中MMPs的免疫评分显著高于非萎缩性口腔扁平苔藓。此外，OSCC中MMP-9的免疫评分显著高于萎缩性和非萎缩性扁平苔藓。此外，TIMP-2和TGF-β1的表达与MMPs的增加平行。
MMPs与TIMPs之间的失衡可能参与口腔扁平苔藓的癌变过程。MMP-2、MT1-MMP，尤其是MMP-9可能是判断口腔扁平苔藓恶变潜能的有用标志物。
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