使用扩散张量纤维束成像技术研究精神分裂症患者小脑与丘脑之间的连接性：一项初步研究。
Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: a pilot study.
作者信息
Magnotta Vincent A, Adix Michael L, Caprahan Arvind, Lim Kelvin, Gollub Randy, Andreasen Nancy C
机构信息
Department of Radiology, The University of Iowa, Iowa, Iowa City, IA 52242, USA.
出版信息
Psychiatry Res. 2008 Aug 30;163(3):193-200. doi: 10.1016/j.pscychresns.2007.10.005. Epub 2008 Jul 25.
Abstract
Connections of the cortical-thalamic-cerebellar-cortical regions provide a framework for studying the neural substrates of schizophrenia. A novel diffusion tensor tractography method was used to evaluate the differences in white matter connectivity between 12 patients with schizophrenia and 10 controls. For the tract tracing, we focused on the connection between the cerebellum and the thalamus. Fractional anisotropy (FA) measures along the fiber tracks were compared between patients and the control sample. Fiber tracts located between the cerebellar white matter and the thalamus exhibit a reduced FA in patients with schizophrenia in comparison with controls. The FA values along the defined fiber tracts were not overall reduced but exhibited a reduction in the anisotropy in the region in the superior cerebellar peduncles projecting towards the red nucleus.
摘要
皮质-丘脑-小脑-皮质区域的连接为研究精神分裂症的神经基质提供了一个框架。一种新型的扩散张量纤维束成像方法被用于评估12例精神分裂症患者和10名对照者之间白质连接性的差异。对于纤维束追踪，我们重点关注小脑与丘脑之间的连接。比较了患者和对照样本沿纤维束的分数各向异性（FA）测量值。与对照相比，精神分裂症患者中位于小脑白质和丘脑之间的纤维束表现出FA降低。沿定义纤维束的FA值并非整体降低，而是在小脑上脚向红核投射区域的各向异性表现出降低。
相似文献
1
Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: a pilot study.使用扩散张量纤维束成像技术研究精神分裂症患者小脑与丘脑之间的连接性：一项初步研究。
Psychiatry Res. 2008 Aug 30;163(3):193-200. doi: 10.1016/j.pscychresns.2007.10.005. Epub 2008 Jul 25.
2
Tract-specific analysis of the superior occipitofrontal fasciculus in schizophrenia.精神分裂症中枕额上束的特定通路分析
Psychiatry Res. 2008 Dec 30;164(3):198-205. doi: 10.1016/j.pscychresns.2008.03.004.
3
Structural and functional dysconnectivity of the fronto-thalamic system in schizophrenia: a DCM-DTI study.精神分裂症中额丘脑系统的结构和功能失调连接：一项基于动态因果模型-扩散张量成像的研究
Cortex. 2015 May;66:35-45. doi: 10.1016/j.cortex.2015.02.004. Epub 2015 Mar 2.
4
Subtle white matter alterations in schizophrenia identified with a new measure of fiber density.利用一种新的纤维密度测量方法发现精神分裂症中的细微的脑白质改变。
Sci Rep. 2019 Mar 15;9(1):4636. doi: 10.1038/s41598-019-40070-2.
5
Changes in cerebellar functional connectivity and anatomical connectivity in schizophrenia: a combined resting-state functional MRI and diffusion tensor imaging study.精神分裂症小脑功能连接和解剖连接的变化：一项静息态功能磁共振成像和弥散张量成像研究。
J Magn Reson Imaging. 2011 Dec;34(6):1430-8. doi: 10.1002/jmri.22784. Epub 2011 Oct 4.
6
Abnormalities in thalamo-cortical connections in patients with first-episode schizophrenia: a two-tensor tractography study.首发精神分裂症患者丘脑-皮质连接异常：双张量轨迹研究。
Brain Imaging Behav. 2019 Apr;13(2):472-481. doi: 10.1007/s11682-018-9862-8.
7
Diffusion tractography of the fornix in schizophrenia.精神分裂症患者穹窿的扩散张量成像
Schizophr Res. 2009 Jan;107(1):39-46. doi: 10.1016/j.schres.2008.10.022. Epub 2008 Nov 30.
8
Alterations in prefrontal connectivity in schizophrenia assessed using diffusion magnetic resonance imaging.使用扩散磁共振成像评估精神分裂症患者前额叶连接性的改变。
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 2;76:107-115. doi: 10.1016/j.pnpbp.2017.03.001. Epub 2017 Mar 10.
9
White matter fractional anisotropy over two time points in early onset schizophrenia and adolescent cannabis use disorder: A naturalistic diffusion tensor imaging study.首发精神分裂症和青少年 cannabis 使用障碍中两个时间点的脑白质各向异性分数：一项自然史扩散张量成像研究。
Psychiatry Res. 2015 Apr 30;232(1):34-41. doi: 10.1016/j.pscychresns.2014.10.010. Epub 2014 Nov 4.
10
White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs.精神分裂症中的白质破坏在空间上广泛存在且在拓扑结构上汇聚于脑网络枢纽。
Schizophr Bull. 2017 Mar 1;43(2):425-435. doi: 10.1093/schbul/sbw100.
引用本文的文献
1
A Pilot Study of Adolescents with Psychotic Experiences: Potential Cerebellar Circuitry Disruption Early Along the Psychosis Spectrum.一项青少年精神病性体验的初步研究：精神病谱早期潜在的小脑环路破坏。
Cerebellum. 2024 Oct;23(5):1772-1782. doi: 10.1007/s12311-023-01579-5. Epub 2023 Jun 23.
2
A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals.哺乳动物小脑直接输出到脑干和间脑的系统评价。
Cerebellum. 2024 Feb;23(1):210-239. doi: 10.1007/s12311-022-01499-w. Epub 2022 Dec 28.
3
Thalamic Connectivity System Across Psychiatric Disorders: Current Status and Clinical Implications.跨精神疾病的丘脑连接系统：现状与临床意义
Biol Psychiatry Glob Open Sci. 2021 Oct 7;2(4):332-340. doi: 10.1016/j.bpsgos.2021.09.008. eCollection 2022 Oct.
4
Consider the pons: bridging the gap on sensory prediction abnormalities in schizophrenia.考虑脑桥：弥合精神分裂症感觉预测异常的鸿沟。
Trends Neurosci. 2022 Nov;45(11):798-808. doi: 10.1016/j.tins.2022.08.008. Epub 2022 Sep 17.
5
Diffusion Tensor Tractography Characteristics of White Matter Tracts are Associated with Post-Stroke Depression.白质纤维束的扩散张量纤维束成像特征与中风后抑郁相关。
Neuropsychiatr Dis Treat. 2021 Jan 25;17:167-181. doi: 10.2147/NDT.S274632. eCollection 2021.
6
The Optogenetic Revolution in Cerebellar Investigations.光遗传学在小脑研究中的革命。
Int J Mol Sci. 2020 Apr 3;21(7):2494. doi: 10.3390/ijms21072494.
7
Functional connectivity of thalamus in children with primary nocturnal enuresis: results from a resting-state fMRI study.丘脑功能连接在原发性夜间遗尿症儿童中的研究：静息态 fMRI 的研究结果。
Brain Imaging Behav. 2021 Feb;15(1):355-363. doi: 10.1007/s11682-020-00262-1.
8
Basal ganglia and cerebellar interconnectivity within the human thalamus.人类丘脑内基底神经节与小脑的相互连接
Brain Struct Funct. 2017 Jan;222(1):381-392. doi: 10.1007/s00429-016-1223-z. Epub 2016 Apr 18.
9
Deep neural network with weight sparsity control and pre-training extracts hierarchical features and enhances classification performance: Evidence from whole-brain resting-state functional connectivity patterns of schizophrenia.具有权重稀疏控制和预训练的深度神经网络提取分层特征并提高分类性能：来自精神分裂症全脑静息态功能连接模式的证据。
Neuroimage. 2016 Jan 1;124(Pt A):127-146. doi: 10.1016/j.neuroimage.2015.05.018. Epub 2015 May 15.
10
Disrupted thalamic resting-state functional networks in schizophrenia.精神分裂症中丘脑静息态功能网络的破坏
Front Behav Neurosci. 2015 Feb 25;9:45. doi: 10.3389/fnbeh.2015.00045. eCollection 2015.
本文引用的文献
1
Neural disorganization in the superior cerebellar peduncle and cognitive abnormality in patients with schizophrenia: A diffusion tensor imaging study.精神分裂症患者上小脑脚的神经组织紊乱与认知异常：一项扩散张量成像研究。
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Dec 30;30(8):1408-12. doi: 10.1016/j.pnpbp.2006.05.014. Epub 2006 Jul 17.
2
Evaluation of the GTRACT diffusion tensor tractography algorithm: a validation and reliability study.GTRACT扩散张量纤维束成像算法的评估：一项验证与可靠性研究。
Neuroimage. 2006 Jul 1;31(3):1075-85. doi: 10.1016/j.neuroimage.2006.01.028. Epub 2006 May 2.
3
Diffusion tensor imaging study of the middle cerebellar peduncles in patients with schizophrenia.精神分裂症患者小脑中脚的扩散张量成像研究
Cerebellum. 2005;4(2):123-7. doi: 10.1080/14734220510007879.
4
Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome.小脑疾病：共济失调、思维辨距障碍和小脑认知情感综合征。
J Neuropsychiatry Clin Neurosci. 2004 Summer;16(3):367-78. doi: 10.1176/jnp.16.3.367.
5
Pathways that make voices: white matter changes in auditory hallucinations.产生幻听的神经通路：幻听中的白质变化
Arch Gen Psychiatry. 2004 Jul;61(7):658-68. doi: 10.1001/archpsyc.61.7.658.
6
Anterior cingulum abnormalities in male patients with schizophrenia determined through diffusion tensor imaging.通过扩散张量成像确定的男性精神分裂症患者前扣带回异常。
Am J Psychiatry. 2004 Mar;161(3):573-5. doi: 10.1176/appi.ajp.161.3.573.
7
Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study.精神分裂症中扣带束完整性破坏：一项磁共振扩散张量成像研究。
Biol Psychiatry. 2003 Dec 1;54(11):1171-80. doi: 10.1016/s0006-3223(03)00419-0.
8
Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study.精神分裂症患者前扣带回异常：一项扩散张量成像研究。
Neuroreport. 2003 Oct 6;14(14):1833-6. doi: 10.1097/00001756-200310060-00015.
9
A diffusion tensor imaging study of middle and superior cerebellar peduncle in male patients with schizophrenia.
Neurosci Lett. 2003 Sep 18;348(3):135-8. doi: 10.1016/s0304-3940(03)00589-5.
10
A unitary model of schizophrenia: Bleuler's "fragmented phrene" as schizencephaly.精神分裂症的统一模型：布鲁勒的“分裂性精神错乱”即脑裂畸形。
Arch Gen Psychiatry. 1999 Sep;56(9):781-7. doi: 10.1001/archpsyc.56.9.781.
Zotero 插件