Cole C J, Kwan A S, Laidlaw D A H, Aylward G W
Vitreoretinal Service, Moorfields Eye Hospital, London, UK.
Br J Ophthalmol. 2008 Oct;92(10):1357-60. doi: 10.1136/bjo.2008.141697. Epub 2008 Jul 29.
To evaluate a new technique in large retinal and choroidal biopsies in patients with uveitis of unknown aetiology and chorioretinal lesions or infiltrate.
Retrospective, non-comparative, consecutive interventional case series. Patients were identified from the computerised patient database and from histopathology records.
A total of nine patients were included in the study. The commonest indication of biopsy was panuveitis of unknown aetiology. Positive histological diagnoses from the chorioretinal biopsies were made in five cases (55.6%). Complications included vitreous haemorrhages and one case of retinal detachment.
The technique of large chorioretinal biopsy described appears to be safe. It produced good amounts of chorioretinal tissue for histopathological analysis. Positive histology results were seen in the majority of the sample and especially in those where vitreous biopsy alone proved to be inadequate.
评估一种用于病因不明的葡萄膜炎及脉络膜视网膜病变或浸润患者的大型视网膜和脉络膜活检新技术。
回顾性、非对比性、连续性干预病例系列研究。通过计算机化患者数据库和组织病理学记录确定患者。
该研究共纳入9例患者。活检最常见的指征是病因不明的全葡萄膜炎。脉络膜视网膜活检组织学诊断阳性5例(55.6%)。并发症包括玻璃体积血和1例视网膜脱离。
所描述的大型脉络膜视网膜活检技术似乎是安全的。它能获取大量脉络膜视网膜组织用于组织病理学分析。大多数样本获得了阳性组织学结果,尤其是那些仅玻璃体活检证明不足的样本。