爱泼斯坦-巴尔病毒与胃癌有关：问题在于其意义何在？
Epstein-Barr virus is associated with gastric carcinoma: the question is what is the significance?
作者信息
Sousa Hugo, Pinto-Correia Ana-L, Medeiros Rui, Dinis-Ribeiro Mario
机构信息
Molecular Oncology Group and Molecular Virology Laboratory, Portuguese Institute of Oncology of Porto, Porto 4200-072, Portugal.
出版信息
World J Gastroenterol. 2008 Jul 21;14(27):4347-51. doi: 10.3748/wjg.14.4347.
AIM
To examine the possible role of the Epstein-Barr Virus (EBV) in the development of gastric adenocarcinoma (GC). It is unclear whether EBV is involved in GC development or is a consequence of gastric inflammation secondary to immunosuppressive treatments.
METHODS
A systematic review was carried out of all published observational studies on the temporal association between EBV and GC, with a view to determine a causal relationship.
RESULTS
The present study showed that the worldwide crude prevalence of EBV in gastric adenocarcinoma was 8.29%. The prevalence varied from 7.08% for intestinal type and 9.82% for diffuse type of GC. It was observed that Western and Central Asian countries had a significantly higher frequency of EBV positive cases compared to South-Eastern countries. America had the highest EBV-GC prevalence whereas Europe had the lowest.
CONCLUSION
The present review has demonstrated a high prevalence of EBV in gastric adenocarcinoma. However, studies designed to assess a temporal relationship and histological association using sensitive techniques should be carried out to establish the role of EBV in GC carcinogenesis.
目的
探讨爱泼斯坦-巴尔病毒（EBV）在胃腺癌（GC）发生发展中的可能作用。目前尚不清楚EBV是参与了GC的发生，还是免疫抑制治疗继发胃炎症的结果。
方法
对所有已发表的关于EBV与GC时间关联的观察性研究进行系统综述，以确定因果关系。
结果
本研究表明，全球范围内EBV在胃腺癌中的粗患病率为8.29%。肠型GC的患病率为7.08%，弥漫型GC的患病率为9.82%。观察到与东南亚国家相比，西亚和中亚国家EBV阳性病例的频率显著更高。美洲的EBV-GC患病率最高，而欧洲最低。
结论
本综述表明EBV在胃腺癌中具有较高的患病率。然而，应开展旨在使用敏感技术评估时间关系和组织学关联的研究，以确定EBV在GC致癌作用中的作用。
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