[Dependence of response reaction of root voles to low-intensity irradiation on the initial state of the tissue antioxidant system].

There has been studied the response of antioxidant (AO) reaction of the tissue system of the root voles Microtus oeconomus Pall. whose parents belonged to the populations long inhabiting the Republic Komi regions with different degrees of radioactive contamination on an additional radiation action at low doses. Differences have been revealed in the phospholipid content, activities of AO defense, intensities of processes of lipid peroxidation (LPO) in tissues of the vole offspring caught in the control and contaminated regions. It has been revealed that direction and degree of changes in the offspring tissues after the additional action are determined by the parameter value in the non-irradiated animal group. Intensity of the LPO processes in liver and brain was leveled after the long low-intensity irradiation. The obtained data and analysis of literature indicate that at predicting effects of chronic action of low doses of a damaging factor both in experiment and in the natural habitation, it is necessary to take into account initial characteristics of biological objects.