内皮素在克氏锥虫感染急性期控制中的作用。
Endothelins role in the control of the acute phase of Trypanosoma cruzi infection.
作者信息
Machado Conceição R S, Camargos Elizabeth R S
机构信息
Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil.
出版信息
Mini Rev Med Chem. 2008 Jul;8(8):820-7. doi: 10.2174/138955708784912184.
Disturbances of endothelin production or clearance contribute to the pathophysiology of several cardiovascular diseases including Chagas disease cardiomyopathy caused by the protozoan Trypanosoma cruzi. In rats, endothelins contribute to control the acute phase, probably by stimulating nitric oxide production. We point out the necessity for new studies to better evaluate high levels of endothelin in the course of other infectious diseases, for which only its detrimental effects have been emphasized.
内皮素生成或清除的紊乱参与了包括由原生动物克氏锥虫引起的恰加斯病心肌病在内的几种心血管疾病的病理生理过程。在大鼠中，内皮素可能通过刺激一氧化氮的产生来控制急性期。我们指出有必要开展新的研究，以更好地评估其他传染病过程中内皮素的高水平情况，目前对于这些传染病仅强调了其有害影响。
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