[Daily practice using the guidelines for prevention and treatment of osteoporosis. Recent evidence of estrogen therapy for osteoporosis].

Results of WHI hormone trial have given the strong restriction on HRT. But recently the conception of adverse events of HRT is getting changed. Generally, it is considered that HRT under 60 years aged or early menopausal women make many benefits without elevation of risk of adverse events and selection of dose level or way to apply can also vary the risk of disease. Because any kind of estrogens has exact effects suppressing bone resorption and fracture, we can use them for osteopenia or osteoporotic women in climacteric state cost-effectively by taking age, dose level and application methods into consideration.