大鼠脑缺血/再灌注期间神经元损伤的变异性及一氧化氮合酶同工型活性比例

Variability of neuronal damage and proportion of activities of NO synthase isoforms during cerebral ischemia/reperfusion in rats.

作者信息

Petrov V I, Pisarev V B, Ponomarev E A, Novochadov V V, Strepetov N N

机构信息

Volgograd State Medical University.

出版信息

Bull Exp Biol Med. 2007 Nov;144(5):657-60. doi: 10.1007/s10517-007-0397-z.

DOI:10.1007/s10517-007-0397-z

PMID:18683488

Abstract

We studied expression of endothelial and neuronal NO synthase isoforms and severity of ischemia/reperfusion-induced damage to neurons in different brain compartments in albino rats. The peculiarities of distribution of NO synthase isoforms in the cerebral cortex and medulla oblongata were determined by different sensitivity of these compartments to ischemic and reperfusion damage to neurons.

摘要

我们研究了白化大鼠不同脑区中内皮型和神经元型一氧化氮合酶同工型的表达以及缺血/再灌注诱导的神经元损伤的严重程度。大脑皮层和延髓中一氧化氮合酶同工型的分布特点取决于这些脑区对神经元缺血和再灌注损伤的不同敏感性。