Weinstein M S, Fried B
Department of Biology, Lafayette College, Easton, PA 18042.
Int J Parasitol. 1991 Apr;21(2):255-7. doi: 10.1016/0020-7519(91)90018-3.
The infectivity and distribution of Echinostoma trivolvis were studied in female ICR mice each infected with 25 metacercarial cysts. At 7 and 10 days post-exposure worm recoveries were 58.8 and 58.4%, respectively. Worm recovery declined to 38.2% by day 14, to 6.4% by day 21, and 0% by day 28. The distribution of the parasites demonstrated an anteriad shift over time. Comparative histopathological studies were carried out on E. trivolvis and Echinostoma caproni in the mouse. Compared to control and E. trivolvis-infected intestine, mouse intestine infected with E. caproni showed marked dilation and villous atrophy. E. trivolvis-infected intestine showed a nearly two-fold increase in goblet cells compared to control intestine, whereas the intestine of E. caproni-infected mice showed almost complete goblet cell loss. Additionally, there was a marked increase in collagen in the intestinal musculature of the mice infected with E. trivolvis compared to control and E. caproni-infected mice.
对每只感染25个囊蚴的雌性ICR小鼠研究了三嵴艾氏吸虫的感染性和分布情况。暴露后7天和10天的虫体回收率分别为58.8%和58.4%。到第14天时虫体回收率降至38.2%，到第21天时降至6.4%，到第28天时为0%。寄生虫的分布随时间呈现向前移位。对小鼠体内的三嵴艾氏吸虫和卡氏艾氏吸虫进行了比较组织病理学研究。与对照和感染三嵴艾氏吸虫的肠道相比，感染卡氏艾氏吸虫的小鼠肠道显示出明显扩张和绒毛萎缩。与对照肠道相比，感染三嵴艾氏吸虫的肠道杯状细胞增加了近两倍，而感染卡氏艾氏吸虫的小鼠肠道杯状细胞几乎完全消失。此外，与对照和感染卡氏艾氏吸虫的小鼠相比，感染三嵴艾氏吸虫的小鼠肠道肌肉组织中的胶原蛋白显著增加。
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