Linssen A, Rothova A, Valkenburg H A, Dekker-Saeys A J, Luyendijk L, Kijlstra A, Feltkamp T E
Department of Ophthalmo-Immunology, The Netherlands Opthalmic Research Institute, Amsterdam.
Invest Ophthalmol Vis Sci. 1991 Aug;32(9):2568-78.
The lifetime cumulative incidence of acute anterior uveitis (AAU) was determined in a sample of a large population (n = 10,500). Nine hundred seventeen subjects, who answered the question "Have you ever had a red eye" in the affirmative in 1977, were asked to participate in a follow-up study 10 years later. From the 917 respondents, 539 were studied completely. A questionnaire was used to collect historic data, and confirmation of these data was obtained from the treating ophthalmologists and physicians. From these data, subjects were selected for an ophthalmologic examination. The respondents also underwent a rheumatologic examination. The results revealed that the lifetime cumulative incidence of definite AAU is approximately 0.2% in the general population and 1% in the histocompatibility antigen HLA-B27-positive population. In one third of the definite AAU patients, the cause of the disease was known. The lifetime cumulative incidence of definite AAU of unknown cause was 0.15% in the general population. When possible and probable AAU are included, the lifetime cumulative incidence of AAU in the general population is about 0.4%. The observed frequency of the concurrence of AAU and ankylosing spondylitis (AS) was 0.4% in the HLA-B27-positive population and 0.02% in the HLA-B27-negative population. Comparison with the expected frequency of the concurrence of AAU and AS revealed that AAU and AS probably are related diseases irrespective of the association of both diseases with HLA-B27.
在一个大样本群体（n = 10500）中确定了急性前葡萄膜炎（AAU）的终生累积发病率。1977年，917名对“您是否曾患过红眼病”问题回答为肯定的受试者被要求在10年后参与一项随访研究。在这917名受访者中，对539人进行了全面研究。使用问卷收集历史数据，并从治疗眼科医生和内科医生处获得这些数据的确认。根据这些数据，挑选受试者进行眼科检查。受访者还接受了风湿病学检查。结果显示，在普通人群中，确诊AAU的终生累积发病率约为0.2%，在组织相容性抗原HLA - B27阳性人群中为1%。在三分之一的确诊AAU患者中，疾病病因已知。在普通人群中，病因不明的确诊AAU的终生累积发病率为0.15%。若将可能的和很可能的AAU包括在内，普通人群中AAU的终生累积发病率约为0.4%。在HLA - B27阳性人群中，观察到的AAU与强直性脊柱炎（AS）并发频率为0.4%，在HLA - B27阴性人群中为0.02%。将AAU与AS并发的观察频率与预期频率进行比较后发现，无论这两种疾病与HLA - B27是否相关，AAU和AS可能都是相关疾病。
