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土耳其的新生儿破伤风;过去十年有哪些变化?

Neonatal tetanus in Turkey; what has changed in the last decade?

作者信息

Dikici Bunyamin, Uzun Hakan, Yilmaz-Keskin Ebru, Tas Taskin, Gunes Ali, Kocamaz Halil, Konca Capan, Tas Mehmet A

机构信息

Duzce University School of Medicine, Department of Pediatrics, Duzce, Turkey.

出版信息

BMC Infect Dis. 2008 Aug 19;8:112. doi: 10.1186/1471-2334-8-112.

Abstract

BACKGROUND

Neonatal tetanus (NT) is still considered as one of the major causes of neonatal death in many developing countries. The aim of the present study was to assess the characteristics of sixty-seven infants with the diagnosis of neonatal tetanus followed-up in the Pediatric Infectious Diseases Ward of Dicle University Hospital, Diyarbakir, between 1991 and 2006, and to draw attention to factors that may contribute (or may have contributed) to the elimination of the disease in Diyarbakir.

METHODS

The data of sixty-seven infants whose epidemiological and clinical findings were compatible with neonatal tetanus were reviewed. Patients were stratified into two groups according to whether they survived or not to assess the effect of certain factors in the prognosis. Factors having a contribution to the higher rate of tetanus among newborn infants were discussed.

RESULTS

A total of 55 cases of NT had been hospitalized between 1991 and 1996 whereas only 12 patients admitted in the last decade. All of the infants had been delivered at home by untrained traditional birth attendants (TBA), and none of the mothers had been immunized with tetanus toxoid during her pregnancy. Twenty-eight (41.8%) of the infants died during their follow-up. Lower birth weight, younger age at onset of symptoms and at the time admission, the presence of opisthotonus, risus sardonicus and were associated with a higher mortality rate.

CONCLUSION

Although the number of neonatal tetanus cases admitted to our clinic in recent years is lower than in the last decade efforts including appropriate health education of the masses, ensurement of access to antenatal sevices and increasing the rate of tetanus immunization among mothers still should be made in our region to achieve the goal of neonatal tetanus elimination.

摘要

背景

在许多发展中国家,新生儿破伤风(NT)仍是新生儿死亡的主要原因之一。本研究旨在评估1991年至2006年间在迪亚巴克尔市迪克莱大学医院儿科传染病病房接受随访的67例诊断为新生儿破伤风的婴儿的特征,并提请注意可能有助于(或可能已经有助于)在迪亚巴克尔消除该疾病的因素。

方法

回顾了67例流行病学和临床发现与新生儿破伤风相符的婴儿的数据。根据患者是否存活将其分为两组,以评估某些因素对预后的影响。讨论了导致新生儿破伤风发病率较高的因素。

结果

1991年至1996年间共收治55例新生儿破伤风病例,而在过去十年中仅收治12例。所有婴儿均由未经培训的传统助产士(TBA)在家中接生,且没有一位母亲在孕期接种过破伤风类毒素。28例(41.8%)婴儿在随访期间死亡。低出生体重、症状出现时和入院时年龄较小、角弓反张、苦笑面容与较高的死亡率相关。

结论

尽管近年来我院收治的新生儿破伤风病例数低于过去十年,但为实现消除新生儿破伤风的目标,我们地区仍应努力开展包括对群众进行适当健康教育、确保获得产前服务以及提高母亲破伤风免疫接种率等工作。

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