Gordy Claire, Dzhagalov Ivan, He You-Wen
Department of Immunology, Duke University Medical Center, Durham, NC 27710, United States.
Semin Immunol. 2009 Feb;21(1):2-7. doi: 10.1016/j.smim.2008.07.002. Epub 2008 Aug 20.
Retinoic acid plays a key role in the development and function of the immune system; however, the contribution of each of the three retinoic acid receptors (RARs) to the T cell immune response is not yet well understood. Of these receptors, both RARalpha and RARgamma are expressed in T lymphocytes. While possible functional redundancy thus complicates understanding of the role of each receptor in T cells, emerging data suggest that RARalpha and RARgamma function differently in thymocyte development and that RARgamma is required for both primary and secondary CD8(+) T cell immune responses.
视黄酸在免疫系统的发育和功能中起关键作用;然而,三种视黄酸受体(RARs)各自对T细胞免疫反应的贡献尚未得到充分了解。在这些受体中,RARα和RARγ均在T淋巴细胞中表达。由于可能存在功能冗余,这使得理解每个受体在T细胞中的作用变得复杂,但新出现的数据表明,RARα和RARγ在胸腺细胞发育中的功能不同,并且RARγ是原发性和继发性CD8(+) T细胞免疫反应所必需的。