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妊娠晚期坏死性胰腺炎的管理

Management of necrotizing pancreatitis in the third trimester of pregnancy.

作者信息

Ducarme Guillaume, Châtel Paul, Alves Arnaud, Hammel Pascal, Luton Dominique

机构信息

Department of Obstetrics and Gynecology, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Université Paris 7, 100, Boulevard du Général Leclerc, 92110 Clichy, France.

出版信息

Arch Gynecol Obstet. 2009 Apr;279(4):561-3. doi: 10.1007/s00404-008-0759-4. Epub 2008 Aug 21.

Abstract

INTRODUCTION

Acute pancreatitis during pregnancy is a severe disease with a high materno-fetal mortality, which recently decreased because of earlier diagnosis and improvement in maternal and neonatal intensive care.

CASE

We describe a 19-year-old woman who presented at 37 weeks gestation with acute abdominal pain and attacks of vomiting. Obstetrical and fetal examinations were normal. Biochemical investigations and magnetic resonance imaging showed a gallstone migration with necrotizing pancreatitis (Balthazar 5 points). Our multidisciplinary team decided on nonsurgical conservative treatment including morphine administration and enteral feeding, and vaginal delivery which was possible 30 h after induction of labor. Follow up was uneventful with a resolution of pain and signs of pancreatitis on imaging.

CONCLUSION

Magnetic resonance imaging can be useful and safe to estimate the severity of acute and necrotizing pancreatitis in the third trimester of pregnancy. In case of sterile necrotizing pancreatitis, nonsurgical conservative treatment and a vaginal delivery should be performed when possible in these patients to reduce the risk of maternal infection.

摘要

引言

妊娠期急性胰腺炎是一种严重疾病,母婴死亡率很高,近年来由于早期诊断以及母婴重症监护的改善,死亡率有所下降。

病例

我们描述了一名19岁女性,在妊娠37周时出现急性腹痛和呕吐发作。产科及胎儿检查均正常。生化检查和磁共振成像显示胆结石移位并伴有坏死性胰腺炎(巴尔萨泽分级5分)。我们的多学科团队决定采取非手术保守治疗,包括给予吗啡和肠内营养,并在引产30小时后进行了阴道分娩。随访过程顺利,疼痛缓解,影像学检查显示胰腺炎体征消失。

结论

磁共振成像对于评估妊娠晚期急性坏死性胰腺炎的严重程度可能是有用且安全的。对于无菌性坏死性胰腺炎患者,应尽可能采取非手术保守治疗并进行阴道分娩,以降低母体感染风险。

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