（±）-三趾树懒氢吡喃酮的仿生合成及结构修正

Biomimetic synthesis and structural revision of (+/-)-tridachiahydropyrone.

作者信息

Sharma Pallavi, Griffiths Nicholas, Moses John E

机构信息

School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

出版信息

Org Lett. 2008 Sep 18;10(18):4025-7. doi: 10.1021/ol8015836. Epub 2008 Aug 22.

DOI:10.1021/ol8015836

PMID:18717585

Abstract

A short synthesis of the revised structure of the marine natural product tridachiahydropyrone is described. A novel biomimetic photochemical electrocyclization was employed to construct the bicyclic carbon framework from an open-chain polyene precursor. The spectroscopic data matched that of the isolated natural product, supporting a revised structure of this complex metabolite.

摘要

描述了海洋天然产物三趾树突氢吡喃的修订结构的简短合成。采用了一种新型的仿生光化学电环化反应，从开链多烯前体构建双环碳骨架。光谱数据与分离得到的天然产物的数据相符，支持了这种复杂代谢物的修订结构。