使用自由基串联反应简短合成（-）-三尖杉碱
Short synthesis of (-)-cephalotaxine using a radical cascade.
作者信息
Taniguchi Tsuyoshi, Ishibashi Hiroyuki
机构信息
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
出版信息
Org Lett. 2008 Sep 18;10(18):4129-31. doi: 10.1021/ol801747m. Epub 2008 Aug 23.
PMID:18720987
Abstract
The short total synthesis of (-)-cephalotaxine is described. The concise construction of the pentacyclic core of this alkaloid was achieved by a radical cascade involving 7-endo and 5-endo cyclizations.
摘要
描述了（-）-三尖杉碱的简短全合成。该生物碱五环核心的简洁构建是通过涉及7-内型和5-内型环化的自由基串联反应实现的。
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