Feser A, Plaza T, Vogelgsang L, Mahler V
Department of Dermatology, University Hospital Erlangen, Hautklinik, Hartmannstrasse 14, Erlangen, Bayern 91052, Germany.
Br J Dermatol. 2008 Sep;159(4):858-63. doi: 10.1111/j.1365-2133.2008.08790.x. Epub 2008 Aug 21.
Periorbital dermatitis is common and frequently recalcitrant to treatment. Due to the exposed and visible location, patients often suffer severely from periorbital dermatitis.
To determine the frequency and causes of periorbital dermatitis including contact sensitizers.
We investigated two cohorts of patients (Erlangen and IVDK without Erlangen) between 1999 and 2004.
The differences between the two cohorts with periorbital dermatitis [Department of Dermatology at University Hospital Erlangen (n = 88) and the German Information Network of Departments of Dermatology (IVDK) collective (n = 2035)] were determined by the MOAHLFA (male, occupational dermatosis, atopic eczema, hand dermatitis, leg dermatitis, facial dermatitis, age > or = 40 years) index. Statistically significant factors for periocular eczema are female sex, atopic skin diathesis and age > or = 40 years. In both cohorts allergic contact dermatitis was the main cause of periorbital eczema (Erlangen 44.3%, IVDK 31.6%), followed by periorbital atopic dermatitis (Erlangen 25%, IVDK 14.1%), airborne dermatitis (Erlangen 10.2%, IVDK 1.9%), irritant contact dermatitis (Erlangen 9.1%, IVDK 7.6%), periorbital rosacea (Erlangen 4.5%, IVDK 2.2%), allergic conjunctivitis (Erlangen 2.3%, IVDK included in 'others') and psoriasis (Erlangen 2.3%, IVDK included in 'others'). The most relevant allergens/allergen sources inducing periorbital eczema were consumers' products (facial cream, eye shadow and ophthalmic therapeutics) (31%), fragrance mix (19%), balsam of Peru (10%), thiomersal (10%) and neomycin sulphate (8%); 12.5% of patients with allergic periocular dermatitis could be exclusively elucidated by testing patients' own products.
Our data demonstrate the multiplicity of causes for periorbital eczematous disease manifestation, which requires patch testing of standard trays as well as consumers' products to elucidate the relevant contact sensitization.
眶周皮炎很常见，且治疗往往难以奏效。由于其暴露且显眼的位置，患者常因眶周皮炎而遭受严重痛苦。
确定眶周皮炎的发生率及病因，包括接触性致敏原。
我们在1999年至2004年间对两组患者（埃尔朗根组和不包括埃尔朗根的德国皮肤科信息网络组）进行了调查。
通过MOAHLFA（男性、职业性皮肤病、特应性湿疹、手部皮炎、腿部皮炎、面部皮炎、年龄≥40岁）指数确定了两组眶周皮炎患者[埃尔朗根大学医院皮肤科（n = 88）和德国皮肤科信息网络（IVDK）汇总组（n = 2035）]之间的差异。眶周湿疹的统计学显著因素为女性、特应性皮肤素质和年龄≥40岁。在两组中，过敏性接触性皮炎都是眶周湿疹的主要病因（埃尔朗根组44.3%，IVDK组31.6%），其次是眶周特应性皮炎（埃尔朗根组25%，IVDK组14.1%）、气源性皮炎（埃尔朗根组10.2%，IVDK组1.9%）、刺激性接触性皮炎（埃尔朗根组9.1%，IVDK组7.6%）、眶周酒渣鼻（埃尔朗根组4.5%，IVDK组2.2%）、过敏性结膜炎（埃尔朗根组2.3%，IVDK组归入“其他”）和银屑病（埃尔朗根组2.3%，IVDK组归入“其他”）。引起眶周湿疹的最相关变应原/变应原来源是消费品（面霜、眼影和眼科治疗剂）（31%）、香料混合物（19%）、秘鲁香脂（10%）、硫柳汞（10%）和硫酸新霉素（8%）；12.5%的过敏性眶周皮炎患者仅通过检测患者自身产品即可明确病因。
我们的数据表明眶周湿疹性疾病表现的病因具有多样性，这需要对标准测试板以及消费品进行斑贴试验，以明确相关的接触致敏情况。
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