To Andrew C Y, Zeng Irene, Coverdale H Arthur
Green Lane Cardiovascular Service, Auckland City Hospital, Park Road, Grafton, Auckland, New Zealand.
Heart Lung Circ. 2008 Dec;17(6):468-74. doi: 10.1016/j.hlc.2008.06.002. Epub 2008 Aug 26.
Patients with severe aortic stenosis, ineligible for surgical aortic valve replacement (AVR), may instead be offered balloon aortic valvuloplasty (BAV). However, initial international enthusiasm for BAV has waned due to early restenosis and symptom recurrence.
We retrospectively reviewed consecutive adult patients who had BAVs in Auckland over a 10-year period from 1997 to 2006 and recorded their clinical, echocardiographic, haemodynamic and follow-up data.
Twenty-nine patients (17F) underwent 35 BAV procedures. There were 26 elderly patients (mean age 87; median logistic EuroSCORE 26%) and 3 patients requiring "bridging" prior to intended AVR at a later interval. Mean changes in left ventricular systolic pressure, aortic systolic pressure and mean gradient were -8%, +16% and -43%, respectively. In the 26 elderly patients, median time to death or recurrence of symptoms was nine months. There was a significant reduction in the number of cardiac-related admissions six months after BAV compared to six months before (p=0.02). Actuarial survival of the elderly patients at 6 months, 1 year and 2 years was 88%, 64%, 31%, respectively. Complications of BAV were 2 reversible neurological events, 2 haematomas and 1 pseudoaneurysm. Re-do BAVs in 5 patients on >or=2 occasions resulted in an improved median actuarial survival of 36 months.
In our experience, BAV has a useful role in symptom palliation in severe aortic stenosis when surgical valve replacement is declined or inappropriate, and can be performed in selected patients with relatively few complications. Re-do BAVs in suitable patients may prolong symptom relief and survival.
重度主动脉瓣狭窄患者若不符合外科主动脉瓣置换术(AVR)的条件,可选择球囊主动脉瓣成形术(BAV)。然而,由于早期再狭窄和症状复发,国际上对BAV最初的热情已有所减退。
我们回顾性分析了1997年至2006年在奥克兰连续接受BAV手术的成年患者,并记录了他们的临床、超声心动图、血流动力学及随访数据。
29例患者(17例女性)接受了35次BAV手术。其中有26例老年患者(平均年龄87岁;逻辑EuroSCORE中位数为26%),3例患者在计划后期进行AVR之前需要“过渡”治疗。左心室收缩压、主动脉收缩压和平均压差的平均变化分别为-8%、+16%和-43%。在26例老年患者中,死亡或症状复发的中位时间为9个月。与BAV术前6个月相比,术后6个月心脏相关住院次数显著减少(p=0.02)。老年患者6个月、1年和2年的精算生存率分别为88%、64%、31%。BAV的并发症包括2例可逆性神经系统事件、2例血肿和1例假性动脉瘤。5例患者接受了≥2次再次BAV手术,其精算生存期中位数提高至36个月。
根据我们的经验,当外科瓣膜置换不可行或不合适时,BAV在重度主动脉瓣狭窄的症状缓解方面具有重要作用,且可在选定患者中进行,并发症相对较少。对合适的患者进行再次BAV手术可能会延长症状缓解期和生存期。