双吡咯菌素、紫素 E 和海兔胺 -1 的全合成。

Total synthesis of dispyrin, purpurealidin E, and aplysamine-1.

作者信息

Yoshida Makoto, Yamaguchi Kentaro

机构信息

Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1362-3. doi: 10.1248/cpb.56.1362.

DOI:10.1248/cpb.56.1362

PMID:18758122

Abstract

Bromotyrosine alkaloids dispyrin (1), purpurealidin E (2), and aplysamine-1 (3) isolated from marine sponge, were synthesized from commercially available tyramine (4) as a common starting material. The overall yield was 18%, 39%, and 22% for 1 from 4 in 5 steps, 2 in 5 steps, and 3 in 6 steps, respectively.

摘要

从海洋海绵中分离出的溴酪氨酸生物碱双吡咯（1）、紫嘌呤E（2）和海兔胺-1（3），以市售的酪胺（4）作为常见起始原料进行合成。以4为原料，分别经5步合成1的总收率为18%，经5步合成2的总收率为39%，经6步合成3的总收率为22%。