肠道糖异生是小鼠胃旁路术后早期代谢变化的关键因素，但在胃束带术后并非如此。

Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.

作者信息

Troy Stephanie, Soty Maud, Ribeiro Lara, Laval Laure, Migrenne Stéphanie, Fioramonti Xavier, Pillot Bruno, Fauveau Veronique, Aubert Roberte, Viollet Benoit, Foretz Marc, Leclerc Jocelyne, Duchampt Adeline, Zitoun Carine, Thorens Bernard, Magnan Christophe, Mithieux Gilles, Andreelli Fabrizio

机构信息

Institut National de la Sante et de la Recherche Medicale, U695, Faculté de Médecine Xavier Bichat, Universite Paris 7, Paris, F-75870, France.

出版信息

Cell Metab. 2008 Sep;8(3):201-11. doi: 10.1016/j.cmet.2008.08.008.

DOI:10.1016/j.cmet.2008.08.008

PMID:18762021

Abstract

Unlike the adjustable gastric banding procedure (AGB), Roux-en-Y gastric bypass surgery (RYGBP) in humans has an intriguing effect: a rapid and substantial control of type 2 diabetes mellitus (T2DM). We performed gastric lap-band (GLB) and entero-gastro anastomosis (EGA) procedures in C57Bl6 mice that were fed a high-fat diet. The EGA procedure specifically reduced food intake and increased insulin sensitivity as measured by endogenous glucose production. Intestinal gluconeogenesis increased after the EGA procedure, but not after gastric banding. All EGA effects were abolished in GLUT-2 knockout mice and in mice with portal vein denervation. We thus provide mechanistic evidence that the beneficial effects of the EGA procedure on food intake and glucose homeostasis involve intestinal gluconeogenesis and its detection via a GLUT-2 and hepatoportal sensor pathway.

摘要

与可调节胃束带手术（AGB）不同，人类的Roux-en-Y胃旁路手术（RYGBP）具有一个有趣的效果：能快速且显著地控制2型糖尿病（T2DM）。我们对喂食高脂饮食的C57Bl6小鼠进行了胃束带（GLB）和肠胃吻合术（EGA）。通过内源性葡萄糖生成测定，EGA手术能特异性地减少食物摄入量并提高胰岛素敏感性。EGA手术后肠道糖异生增加，但胃束带手术后未增加。在GLUT-2基因敲除小鼠和门静脉去神经支配的小鼠中，所有EGA的效果均被消除。因此，我们提供了机制证据，表明EGA手术对食物摄入和葡萄糖稳态的有益作用涉及肠道糖异生及其通过GLUT-2和肝门静脉传感器途径的检测。