白细胞介素-10是小鼠中耳炎模型中黏液样化生的重要调节因子。
Interleukin-10 is an essential modulator of mucoid metaplasia in a mouse otitis media model.
作者信息
Tsuchiya Katsuyuki, Komori Masahiro, Zheng Qing Yin, Ferrieri Patricia, Lin Jizhen
机构信息
University of Minnesota Otitis Media Research Center, Department of Otolaryngology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
出版信息
Ann Otol Rhinol Laryngol. 2008 Aug;117(8):630-6. doi: 10.1177/000348940811700814.
OBJECTIVES
Inflammatory cytokines are involved in the development of mucous cell metaplasia and hyperplasia (MCM) in otitis media (OM). However, which cytokines play an essential role in the MCM of OM is not clear at the moment.
METHODS
In this study, we hypothesized that interleukin-10 (IL-10) played an indispensable role in the MCM of bacterial OM, and we used IL-10 knockout mice to test this hypothesis.
RESULTS
In wild-type mice, both Streptococcus pneumoniae and Haemophilus influenzae triggered the development of MCM in the middle ear mucosa. In IL-10 knockout mice, the number of goblet cells and mucin-producing cells in the middle ear was significantly reduced after bacterial middle ear infection compared with that in wild-type mice.
CONCLUSIONS
We conclude that IL-10 plays an essential role in the MCM of bacterial OM. Interleukin-10 is a potential target for the treatment of MCM in OM.
目的
炎性细胞因子参与中耳炎（OM）中黏液细胞化生和增生（MCM）的发展。然而，目前尚不清楚哪些细胞因子在中耳炎的MCM中起关键作用。
方法
在本研究中，我们假设白细胞介素-10（IL-10）在细菌性中耳炎的MCM中起不可或缺的作用，并使用IL-10基因敲除小鼠来验证这一假设。
结果
在野生型小鼠中，肺炎链球菌和流感嗜血杆菌均可引发中耳黏膜MCM的发展。与野生型小鼠相比，在IL-10基因敲除小鼠中，细菌感染中耳后，中耳杯状细胞和黏液分泌细胞的数量显著减少。
结论
我们得出结论，IL-10在细菌性中耳炎的MCM中起关键作用。白细胞介素-10是治疗中耳炎MCM的潜在靶点。
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