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来自巴基斯坦、土耳其和索马里的移民母亲及其在挪威儿童健康诊所就诊的婴儿的维生素D状况。

Vitamin D status among immigrant mothers from Pakistan, Turkey and Somalia and their infants attending child health clinics in Norway.

作者信息

Madar Ahmed A, Stene Lars C, Meyer Haakon E

机构信息

Institute of General Practice and Community Medicine, University of Oslo, PO Box 1130, Blindern, N-0318 Oslo, Norway.

出版信息

Br J Nutr. 2009 Apr;101(7):1052-8. doi: 10.1017/S0007114508055712. Epub 2008 Sep 9.

Abstract

High prevalences of vitamin D deficiency have been reported in non-Western immigrants moving to Western countries, including Norway, but there is limited information on vitamin D status in infants born to immigrant mothers. We aimed to describe the vitamin D status and potentially correlated factors among infants aged 6 weeks and their mothers with Pakistani, Turkish or Somali background attending child health clinics in Norway. Eighty-six healthy infants and their mothers with immigrant background were recruited at the routine 6-week check-up at nine centres between 2004 and 2006. Venous or capillary blood was collected at the clinics from the mother and infant, and serum separated for analysis of 25-hydroxyvitamin D (s-25(OH)D) and intact parathyroid hormone (s-iPTH). The mean maternal s-25(OH)D was 25.8 nmol/l, with 57 % below 25 nmol/l and 15 % below 12.5 nmol/l. Of the mothers, 26 % had s-iPTH>5.7 pmol/l. For infants, mean s-25(OH)D was 41.7 nmol/l, with 47 % below 25 nmol/l and 34 % below 12.5 nmol/l. s-25(OH)D was considerably lower in the thirty-one exclusively breast-fed infants (mean 11.1 nmol/l; P < 0.0001). Use of vitamin D supplements and education showed a positive association with maternal s-25(OH)D. There was no significant association between mother's and child's s-25(OH)D, and no significant ethnic or seasonal variation in s-25(OH)D for mothers or infants. In conclusion, there is widespread vitamin D deficiency in immigrant mothers and their infants living in Norway. Exclusively breast-fed infants who did not receive vitamin D supplements had particularly severe vitamin D deficiency.

摘要

据报道,包括挪威在内,移民到西方国家的非西方移民中维生素D缺乏症的患病率很高,但关于移民母亲所生孩子的维生素D状况的信息有限。我们旨在描述挪威儿童健康诊所中6周龄婴儿及其具有巴基斯坦、土耳其或索马里背景的母亲的维生素D状况以及潜在的相关因素。2004年至2006年期间,在九个中心的常规6周检查中招募了86名有移民背景的健康婴儿及其母亲。在诊所采集母亲和婴儿的静脉血或毛细血管血,分离血清以分析25-羟基维生素D(s-25(OH)D)和完整甲状旁腺激素(s-iPTH)。母亲的平均s-25(OH)D为25.8 nmol/l,57%低于25 nmol/l,15%低于12.5 nmol/l。母亲中,26%的s-iPTH>5.7 pmol/l。对于婴儿,平均s-25(OH)D为41.7 nmol/l,47%低于25 nmol/l,34%低于12.5 nmol/l。31名纯母乳喂养婴儿的s-25(OH)D明显较低(平均11.1 nmol/l;P<0.0001)。维生素D补充剂的使用和教育与母亲的s-25(OH)D呈正相关。母亲和孩子的s-25(OH)D之间没有显著关联,母亲或婴儿的s-25(OH)D也没有显著的种族或季节差异。总之,居住在挪威的移民母亲及其婴儿中普遍存在维生素D缺乏症。未接受维生素D补充剂的纯母乳喂养婴儿维生素D缺乏症尤为严重。

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