微环境的几何和空间限制诱导少突胶质细胞分化。
The geometric and spatial constraints of the microenvironment induce oligodendrocyte differentiation.
作者信息
Rosenberg Sheila S, Kelland Eve E, Tokar Eleonora, De la Torre Asia R, Chan Jonah R
机构信息
Neuroscience Graduate Program and Department of Biochemistry and Molecular Biology, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
出版信息
Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14662-7. doi: 10.1073/pnas.0805640105. Epub 2008 Sep 11.
The oligodendrocyte precursor cell (OPC) arises from the subventricular zone (SVZ) during early vertebrate development to migrate and proliferate along axon tracts before differentiating into the myelin-forming oligodendrocyte. We demonstrate that the spatial and temporal regulation of oligodendrocyte differentiation depends intimately on the axonal microenvironment and the density of precursor cells along a specified axonal area. Differentiation does not require dynamic axonal signaling, but instead is induced by packing constraints resulting from intercellular interactions. Schwann cells and even artificial beads bound to the axonal surface can mimic these constraints and promote differentiation. Together, these results describe the coordinately controlled biophysical interaction of oligodendrocyte precursors within an axonal niche leading to self-renewal and differentiation.
少突胶质前体细胞（OPC）在脊椎动物早期发育过程中起源于脑室下区（SVZ），在分化为形成髓鞘的少突胶质细胞之前，沿轴突束迁移并增殖。我们证明，少突胶质细胞分化的时空调节密切依赖于轴突微环境以及特定轴突区域上前体细胞的密度。分化并不需要动态的轴突信号传导，而是由细胞间相互作用产生的堆积限制所诱导。施万细胞甚至与轴突表面结合的人工珠子都可以模拟这些限制并促进分化。总之，这些结果描述了轴突生态位内少突胶质前体细胞的协同控制的生物物理相互作用，从而导致自我更新和分化。
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