暴发性1型糖尿病患者无论年龄和性别，临床及HLA - DR状态均具有一致性。
Uniformity in clinical and HLA-DR status regardless of age and gender within fulminant type 1 diabetes.
作者信息
Imagawa Akihisa, Hanafusa Toshiaki, Iwahashi Hiromi, Uchigata Yasuko, Kanatsuka Azuma, Kawasaki Eiji, Kobayashi Tetsuro, Shimada Akira, Shimizu Ikki, Maruyama Taro, Makino Hideichi
机构信息
First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki 569-8686, Japan.
出版信息
Diabetes Res Clin Pract. 2008 Nov;82(2):233-7. doi: 10.1016/j.diabres.2008.08.003. Epub 2008 Sep 11.
To clarify the detailed clinical features and HLA subtype in the patients with fulminant type 1 diabetes, we investigated consecutive 250 case records registered to the committee of the Japan Diabetes Society between 2000/7/15 and 2006/6/30. After the classification with age at onset or gender, clinical data and HLA DR were evaluated. As a result, the prevalence of male patients, BMI, HbA(1c) and ALT levels at the onset increased significantly according to the elder quartile, but no other data showed any significant difference. Only age at onset and blood glucose level were significantly higher in male patients than in female patients without pregnancy by multivariate analysis. The distribution of HLA DR was not different in any subtype by gender or age at onset. Our present study revealed common feature in clinical and HLA-DR status regardless of age and gender within fulminant type 1 diabetes except pregnant women.
为阐明暴发性 1 型糖尿病患者的详细临床特征和 HLA 亚型，我们调查了 2000 年 7 月 15 日至 2006 年 6 月 30 日期间向日本糖尿病学会委员会登记的连续 250 例病例记录。按发病年龄或性别进行分类后，对临床数据和 HLA DR 进行了评估。结果显示，男性患者的患病率、发病时的 BMI、糖化血红蛋白（HbA1c）和谷丙转氨酶（ALT）水平随年龄四分位数的增加而显著升高，但其他数据未显示出任何显著差异。多因素分析显示，仅发病年龄和血糖水平在非妊娠男性患者中显著高于女性患者。HLA DR 的分布在按性别或发病年龄划分的任何亚型中均无差异。我们目前的研究揭示了除孕妇外，暴发性 1 型糖尿病患者在临床和 HLA - DR 状态方面存在与年龄和性别无关的共同特征。
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