CART肽：体重、奖赏及其他功能的调节因子。
CART peptides: regulators of body weight, reward and other functions.
作者信息
Rogge G, Jones D, Hubert G W, Lin Y, Kuhar M J
机构信息
Neuroscience Division, Yerkes National Primate Research Center of Emory University, 954 Gatewood Road NE, Atlanta, Georgia 30329, USA.
出版信息
Nat Rev Neurosci. 2008 Oct;9(10):747-58. doi: 10.1038/nrn2493.
Abstract
Over the past decade or so, CART (cocaine- and amphetamine-regulated transcript) peptides have emerged as major neurotransmitters and hormones. CART peptides are widely distributed in the CNS and are involved in regulating many processes, including food intake and the maintenance of body weight, reward and endocrine functions. Recent studies have produced a wealth of information about the location, regulation, processing and functions of CART peptides, but additional studies aimed at elucidating the physiological effects of the peptides and at characterizing the CART receptor(s) are needed to take advantage of possible therapeutic applications.
摘要
在过去十年左右的时间里，可卡因和苯丙胺调节转录肽（CART）已成为主要的神经递质和激素。CART肽广泛分布于中枢神经系统，并参与调节许多生理过程，包括食物摄入、体重维持、奖赏和内分泌功能。最近的研究已经产生了大量关于CART肽的定位、调节、加工和功能的信息，但还需要进一步的研究来阐明这些肽的生理作用，并对CART受体进行表征，以便利用其可能的治疗应用。
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本文引用的文献
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Injection of CART (cocaine- and amphetamine-regulated transcript) peptide into the nucleus accumbens reduces cocaine self-administration in rats.向大鼠伏隔核注射CART（可卡因和苯丙胺调节转录物）肽可减少其可卡因自我给药行为。
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Gene regulation in the frontal cortex of rats exposed to the chronic mild stress paradigm, an animal model of human depression.暴露于慢性轻度应激范式（一种人类抑郁症动物模型）的大鼠额叶皮质中的基因调控。
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Anti-obesity drugs and neural circuits of feeding.抗肥胖药物与进食神经回路
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Cocaine administration increases the fraction of CART cells in the rat nucleus accumbens that co-immunostain for c-Fos.给予可卡因会增加大鼠伏隔核中与c-Fos共免疫染色的可卡因-和酪酪肽（CART）细胞的比例。
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Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens.血清素5-HT4受体激活所诱导的厌食症是由伏隔核中可卡因及苯丙胺调节转录肽（CART）增加介导的。
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Cocaine- and amphetamine-regulated transcript peptide (CART) is present in peptidergic C primary afferents and axons of excitatory interneurons with a possible role in nociception in the superficial laminae of the rat spinal cord.可卡因和苯丙胺调节转录肽（CART）存在于肽能C类初级传入纤维和兴奋性中间神经元的轴突中，可能在大鼠脊髓浅层的伤害感受中发挥作用。
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