稳定氮丙啶离子的制备及其开环反应。

The preparation of stable aziridinium ions and their ring-openings.

作者信息

Kim Yongeun, Ha Hyun-Joon, Yun Sae Young, Lee Won Koo

机构信息

Department of Chemistry and Protein Centre for Bio-Industry, Hankuk University of Foreign Studies, Yongin 449-791, Korea.

出版信息

Chem Commun (Camb). 2008 Sep 28(36):4363-5. doi: 10.1039/b809124b. Epub 2008 Jul 24.

DOI:10.1039/b809124b

PMID:18802571

Abstract

The reaction of enantiomerically pure 2-substituted 1-phenylethyl-aziridine with methyl trifluoromethanesulfonate generated a stable methylaziridinium ion, which was reacted with various external nucleophiles, including nitrile, to yield synthetically valuable and optically pure acyclic amine derivatives in a completely regio- and stereoselective manner.

摘要

对映体纯的2-取代-1-苯乙基氮丙啶与三氟甲磺酸甲酯反应生成了一种稳定的甲基氮丙啶鎓离子，该离子与包括腈在内的各种外部亲核试剂反应，以完全区域和立体选择性的方式生成具有合成价值的光学纯无环胺衍生物。