Semmelweis University, Budapest, Hungary.
Pathol Oncol Res. 2009 Sep;15(3):307-13. doi: 10.1007/s12253-008-9099-8.
The aim of our study was to find the cause of urinary incontinence and voiding dysfunction in patients undergoing radical cystectomy and orthotopic bladder replacement with modified ileal neobladder (Reddy). Twenty-eight incontinent patients (operated on between 1988 and 2004) were involved in our examination. Based on the complaints of the patients, continence status was evaluated and divided into two groups: group I: partially incontinent (only night-time incontinence) n = 11 (39.3%) and group II: totally incontinent (night-time and daytime incontinence) n = 17 (60.7%). Detailed urodynamic examination (enterocystometry and urethral pressure profile) in addition to involuntary neobladder contractions and capacity detection were carried out on all patients. Furthermore resting pressure and maximal voluntary contraction ability of the sphincter were determined and statistically analyzed in both groups. Significant difference was noticed in resting pressure and maximal voluntary contraction ability of the sphincter among the partially incontinent and totally incontinent patients. Frequency, intensity and duration of involuntary neobladder contractions also showed significant differences between the two groups. Incontinence of neobladder depends not only on the destruction of resting and contraction capability of the urethral sphincter, but also on the presence or absence of involuntary contractions in the wall of the neobladder and decreased capacity of the neobladder.
我们的研究目的是找到接受根治性膀胱切除术和改良回肠代膀胱(Reddy)原位膀胱替代术的患者出现尿失禁和排尿功能障碍的原因。我们检查了 28 名失禁患者(1988 年至 2004 年间手术)。根据患者的主诉,评估了他们的控尿状况,并将其分为两组:I 组:部分失禁(仅夜间失禁)11 例(39.3%);II 组:完全失禁(夜间和白天失禁)17 例(60.7%)。对所有患者进行详细的尿动力学检查(肠膀胱测压和尿道压力描记),以及非自愿性新膀胱收缩和容量检测。此外,还在两组患者中确定并统计分析了括约肌的静息压力和最大自主收缩能力。部分失禁和完全失禁患者之间的括约肌静息压力和最大自主收缩能力存在显著差异。非自愿性新膀胱收缩的频率、强度和持续时间在两组之间也存在显著差异。新膀胱的失禁不仅取决于尿道括约肌的静息和收缩能力的破坏,还取决于新膀胱壁是否存在非自愿收缩以及新膀胱容量的减少。