Ortonne J P, Perrot H, Thivolet J
Sem Hop. 1976 Mar 16;52(11):679-86.
A study of 100 cases of vitiligo showed the frequency of associated skin and visceral lesions. A skin disease was associated in 24 cases: psoriasis 4 cases, alopecia 4 cases, eczema 3 cases, malignant melanoma 2 cases, dermatitis herpetiformis 1 case, lichen planus 9 cases. However, only one case of Sutton's naevus was noted. Among other associations noted in 28 cases, there were 7 cases of thyroid disease, 5 cases of diabetes, 1 case of chronic rheumatoid arthritis and 3 gastric disorders. The frequency of these various associations was discussed in the light of other authors' reports. If one compares the 21 cases associated with auto-immune disease and the other cases of vitiligo, there was no significant difference for the various parameters studied. Thus the significance of the various biological signs of autoimmunisation remains doubtful and even the precise definition of vitiligo remains uncertain.
一项对100例白癜风患者的研究显示了相关皮肤和内脏病变的发生率。24例患者伴有皮肤病：银屑病4例、脱发4例、湿疹3例、恶性黑色素瘤2例、疱疹样皮炎1例、扁平苔藓9例。然而，仅发现1例萨顿痣。在28例其他相关疾病中，有7例甲状腺疾病、5例糖尿病、1例慢性类风湿性关节炎和3例胃部疾病。根据其他作者的报告对这些不同相关疾病的发生率进行了讨论。如果将21例与自身免疫性疾病相关的病例与其他白癜风病例进行比较，所研究的各项参数并无显著差异。因此，自身免疫各种生物学迹象的意义仍值得怀疑，甚至白癜风的确切定义也仍不明确。
