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加拿大胎儿酒精谱系障碍筛查工具的开发。

Development of Canadian screening tools for fetal alcohol spectrum disorder.

作者信息

Goh Y Ingrid, Chudley Albert E, Clarren Sterling K, Koren Gideon, Orrbine Elaine, Rosales Ted, Rosenbaum Charlotte

机构信息

The Motherisk Program, Division of Clinical Pharmacology & Toxicology, The Hospital for Sick Children, Toronto, Ontario.

出版信息

Can J Clin Pharmacol. 2008 Summer;15(2):e344-66. Epub 2008 Sep 5.

Abstract

BACKGROUND

Fetal alcohol spectrum disorder (FASD) is the most common cause of neurobehavioural handicap in North America. Screening for FASD may facilitate diagnosis and hence management of these children. We present a variety of screening tools for the identification of children at risk for FASD.

METHODS

We critically reviewed and evaluated published and practiced methods for their potential of screening suspected cases, their epidemiological characteristics (sensitivity, specificity, positive and negative predictive values) [Phase I], as well as their feasibility [Phase II].

RESULTS

The following five tools were selected for the FASD screening toolkit: screening fatty acid ethyl esters in neonatal meconium, the modified Child Behaviour Checklist, Medicine Wheel tool, Asante Centre Probation Officer Tool, and maternal history of drinking and drug use.

CONCLUSIONS

The toolkit for FASD screening aims at screening different populations, from the newborns to youth and at-risk mothers. It is anticipated that the toolkit will facilitate diagnosis of FASD.

摘要

背景

胎儿酒精谱系障碍(FASD)是北美神经行为障碍最常见的病因。对FASD进行筛查可能有助于这些儿童的诊断及后续管理。我们介绍了多种用于识别FASD高危儿童的筛查工具。

方法

我们严格审查并评估了已发表及实际应用的方法,评估其筛查疑似病例的潜力、流行病学特征(敏感性、特异性、阳性和阴性预测值)[第一阶段]以及可行性[第二阶段]。

结果

为FASD筛查工具包选择了以下五种工具:检测新生儿胎粪中的脂肪酸乙酯、改良版儿童行为量表、药轮工具、阿桑特中心缓刑监督官工具以及母亲饮酒和药物使用史。

结论

FASD筛查工具包旨在筛查从新生儿到青少年以及高危母亲等不同人群。预计该工具包将有助于FASD的诊断。

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