结直肠癌中染色体不稳定的有丝分裂起源
Mitotic Origins of Chromosomal Instability in Colorectal Cancer.
作者信息
Dalton W Brian, Yang Vincent W
出版信息
Curr Colorectal Cancer Rep. 2007 Apr;3(2):59-64. doi: 10.1007/s11888-007-0001-y.
Abstract
Mitosis is a crucial part of the cell cycle. A successful mitosis requires the proper execution of many complex cellular behaviors. Thus, there are many points at which mitosis may be disrupted. In cancer cells, chronic disruption of mitosis can lead to unequal segregation of chromosomes, a phenomenon known as chromosomal instability. A majority of colorectal tumors suffer from this instability, and recent studies have begun to reveal the specific ways in which mitotic defects promote chromosomal instability in colorectal cancer.
摘要
有丝分裂是细胞周期的关键部分。成功的有丝分裂需要正确执行许多复杂的细胞行为。因此，有丝分裂可能在许多环节被破坏。在癌细胞中，有丝分裂的长期破坏会导致染色体的不均等分离，这种现象被称为染色体不稳定。大多数结直肠肿瘤都存在这种不稳定性，最近的研究已开始揭示有丝分裂缺陷促进结直肠癌染色体不稳定的具体方式。
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