韩国出现对金刚烷胺耐药的H3N2甲型禽流感病毒。
Emergence of amantadine-resistant H3N2 avian influenza A virus in South Korea.
作者信息
Lee Jiyeon, Song Young Jun, Park Jeung Hyun, Lee Jun-Han, Baek Yun Hee, Song Min-Suk, Oh Taek-Kyu, Han Heon-Seok, Pascua Philippe Noriel Q, Choi Young-Ki
机构信息
College of Medicine and Medical Research Institute, Chungbuk National University, 12 Gaeshin-Dong Heungduk-Ku, Cheongju 361-763, Republic of Korea.
出版信息
J Clin Microbiol. 2008 Nov;46(11):3788-90. doi: 10.1128/JCM.01427-08. Epub 2008 Sep 24.
Abstract
We found a relatively high frequency of unique amantadine-resistant H3N2 and H9N2 avian influenza viruses (Val27Ile on M2 protein) isolated from live poultry markets in South Korea and confirmed that a Val27Ile single substitution in the M2 protein is enough to acquire the amantadine resistance phenotype by using reverse-genetically created human-avian reassortant viruses.
摘要
我们发现从韩国活禽市场分离出的具有独特金刚烷胺抗性的H3N2和H9N2禽流感病毒（M2蛋白上的Val27Ile）频率相对较高，并通过使用反向遗传构建的人禽重配病毒证实M2蛋白中的Val27Ile单取代足以获得金刚烷胺抗性表型。
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