扫描离子束运动补偿：一项技术可行性研究。
Motion compensation with a scanned ion beam: a technical feasibility study.
作者信息
Grözinger Sven Oliver, Bert Christoph, Haberer Thomas, Kraft Gerhard, Rietzel Eike
机构信息
Gesellschaft für Schwerionenforschung, Abteilung Biophysik, Darmstadt, Germany.
出版信息
Radiat Oncol. 2008 Oct 14;3:34. doi: 10.1186/1748-717X-3-34.
BACKGROUND
Intrafractional motion results in local over- and under-dosage in particle therapy with a scanned beam. Scanned beam delivery offers the possibility to compensate target motion by tracking with the treatment beam.
METHODS
Lateral motion components were compensated directly with the beam scanning system by adapting nominal beam positions according to the target motion. Longitudinal motion compensation to mitigate motion induced range changes was performed with a dedicated wedge system that adjusts effective particle energies at isocenter.
RESULTS
Lateral compensation performance was better than 1% for a homogeneous dose distribution when comparing irradiations of a stationary radiographic film and a moving film using motion compensation. The accuracy of longitudinal range compensation was well below 1 mm.
CONCLUSION
Motion compensation with scanned particle beams is technically feasible with high precision.
背景
在扫描束粒子治疗中，分次内运动导致局部剂量过高和过低。扫描束输送提供了通过用治疗束跟踪来补偿靶运动的可能性。
方法
通过根据靶运动调整标称束位置，利用束扫描系统直接补偿横向运动分量。使用专用楔形系统进行纵向运动补偿以减轻运动引起的射程变化，该系统可调整等中心处的有效粒子能量。
结果
在使用运动补偿对静止射线照相胶片和移动胶片进行照射时，对于均匀剂量分布，横向补偿性能优于1%。纵向射程补偿的精度远低于1毫米。
结论
扫描粒子束的运动补偿在技术上具有高精度的可行性。
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