基于壳聚糖和聚乳酸的用于伤口敷料应用的电纺非织造纳米纤维混合垫。
Electrospun non-woven nanofibrous hybrid mats based on chitosan and PLA for wound-dressing applications.
作者信息
Ignatova Milena, Manolova Nevena, Markova Nadya, Rashkov Iliya
机构信息
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev 103A, 1113 Sofia, Bulgaria.
出版信息
Macromol Biosci. 2009 Jan 9;9(1):102-11. doi: 10.1002/mabi.200800189.
Continuous defect-free nanofibers containing chitosan (Ch) or quaternized chitosan (QCh) were successfully prepared by one-step electrospinning of Ch or QCh solutions mixed with poly[(L-lactide)-co-(D,L-lactide)] in common solvent. XPS revealed the surface chemical composition of the bicomponent electrospun mats. Crosslinked Ch- and QCh-containing nanofibers exhibited higher kill rates against bacteria S. aureus and E. coli than the corresponding solvent-cast films. SEM observations showed that hybrid mats were very effective in suppressing the adhesion of pathogenic bacteria S. aureus. The hybrid nanofibers are promising for wound-healing applications.
通过在普通溶剂中将壳聚糖（Ch）或季铵化壳聚糖（QCh）溶液与聚[（L-丙交酯）-共-（D，L-丙交酯）]混合进行一步电纺丝，成功制备了含壳聚糖或季铵化壳聚糖的连续无缺陷纳米纤维。X射线光电子能谱（XPS）揭示了双组分电纺垫的表面化学成分。与相应的溶剂浇铸膜相比，含交联壳聚糖和季铵化壳聚糖的纳米纤维对金黄色葡萄球菌和大肠杆菌表现出更高的杀灭率。扫描电子显微镜（SEM）观察表明，混合垫在抑制金黄色葡萄球菌的粘附方面非常有效。这种混合纳米纤维在伤口愈合应用方面具有广阔前景。
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