美国的人类嗜T淋巴细胞病毒I型相关脊髓病/热带痉挛性截瘫
HTLV-I-associated myelopathy/tropical spastic paraparesis in the United States.
作者信息
Janssen R S, Kaplan J E, Khabbaz R F, Hammond R, Lechtenberg R, Lairmore M, Chiasson M A, Punsalang A, Roberts B, McKendall R R
机构信息
Retrovirus Diseases Branch, Centers for Disease Control, Atlanta, GA 30333.
出版信息
Neurology. 1991 Sep;41(9):1355-7. doi: 10.1212/wnl.41.9.1355.
HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is endemic in the Caribbean basin and Japan. Because of the close proximity of the United States to the Caribbean and the presence of HTLV-I-seropositive persons in the United States, we sought reports of patients who were HTLV-I seropositive and had a slowly progressive myelopathy. Over a 2-year period, there were 25 patients reported, 19 of whom were black and 12 of whom had been born in the United States. All patients except two had become symptomatic while living in the United States. Six patients had no apparent risk factor for acquiring HTLV-I. These data demonstrate that HAM/TSP is occurring in the United States and that the diagnosis of HAM/TSP should be considered in patients with a slowly progressive myelopathy regardless of risk factors for acquiring HTLV-I.
人类嗜T淋巴细胞病毒I型相关脊髓病/热带痉挛性截瘫（HAM/TSP）在加勒比海盆地和日本呈地方流行。由于美国与加勒比海地区地理位置接近，且美国存在人类嗜T淋巴细胞病毒I型血清反应阳性者，我们查找了人类嗜T淋巴细胞病毒I型血清反应阳性且患有缓慢进展性脊髓病患者的报告。在两年时间里，共报告了25例患者，其中19例为黑人，12例出生在美国。除2例患者外，所有患者均在美国居住期间出现症状。6例患者没有明显的感染人类嗜T淋巴细胞病毒I型的危险因素。这些数据表明，美国正在发生HAM/TSP，对于患有缓慢进展性脊髓病的患者，无论其感染人类嗜T淋巴细胞病毒I型的危险因素如何，均应考虑HAM/TSP的诊断。
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