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Site-directed mutagenesis reveals putative substrate binding residues in the Escherichia coli RND efflux pump AcrB.
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MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli.
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Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF).
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Common recognition topology of mex transporters of revealed by molecular modelling.
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New Topoisomerase Inhibitors: Evaluating the Potency of Gepotidacin and Zoliflodacin in Fluoroquinolone-Resistant Escherichia coli upon Inactivation and Differentiating Their Efflux Pump Substrate Nature.
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本文引用的文献
1
Site-directed mutagenesis reveals putative substrate binding residues in the Escherichia coli RND efflux pump AcrB.
J Bacteriol. 2008 Dec;190(24):8225-9. doi: 10.1128/JB.00912-08. Epub 2008 Oct 10.
2
Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors.
PLoS Biol. 2007 Jan;5(1):e7. doi: 10.1371/journal.pbio.0050007.
3
Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF).
J Antimicrob Chemother. 2007 Jun;59(6):1216-22. doi: 10.1093/jac/dkl426. Epub 2006 Oct 24.
4
Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.
Science. 2006 Sep 1;313(5791):1295-8. doi: 10.1126/science.1131542.
5
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.
Nature. 2006 Sep 14;443(7108):173-9. doi: 10.1038/nature05076. Epub 2006 Aug 16.
6
Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.
Clin Microbiol Rev. 2006 Apr;19(2):382-402. doi: 10.1128/CMR.19.2.382-402.2006.
7
Mutations in the central cavity and periplasmic domain affect efflux activity of the resistance-nodulation-division pump EmhB from Pseudomonas fluorescens cLP6a.
J Bacteriol. 2006 Jan;188(1):115-23. doi: 10.1128/JB.188.1.115-123.2006.
8
A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study.
J Bacteriol. 2005 Oct;187(19):6804-15. doi: 10.1128/JB.187.19.6804-6815.2005.
9
Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa.
J Bacteriol. 2004 Mar;186(5):1258-69. doi: 10.1128/JB.186.5.1258-1269.2004.
10
Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria.
J Bacteriol. 2002 Dec;184(23):6499-507. doi: 10.1128/JB.184.23.6499-6507.2002.
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